Overview

  • Product name

    4-DAMP, Muscarinic receptor antagonist
  • Description

    Muscarinic receptor antagonist
  • Biological description

    Muscarinic antagonist. (Ki values for human receptors are 0.57 (M1), 7.3 (M2), 0.37 (M3), 0.72 (M4) and 0.55 nM (M5)).
  • Purity

    > 98%
  • CAS Number

    1952-15-4
  • Chemical structure

    Chemical Structure

Properties

Images

  • (A) rhAQP5 vector-transfected HSG cells were stimulated with CCh (100 µM) in the presence or absence of 4-DAMP (10 µM), prenzepine (10 µM), and mixture of 4-DAMP and prenzepine (M3R or M1R specific antagonist, respectively).
    (B) To monitor hAQP5 trafficking, original GFP pictures in (A) were converted into 'Fire' 3D LUT (lookup tables) setting in ImageJ software and only GFP signal above the fluorescent signal threshold (?80, red or yellow color in converted picture), was captured in (B) as positive GFP signal. Yellow arrows indicate the positive GFP signal on the membrane and green arrows indicates signal in the cytoplasm in HSG cells.

References

This product has been referenced in:

  • Ishii M & Kurachi Y Muscarinic acetylcholine receptors. Curr Pharm Des 12:3573-81 (2006). Read more (PubMed: 17073660) »
  • Moriya H  et al. Affinity profiles of various muscarinic antagonists for cloned human muscarinic acetylcholine receptor (mAChR) subtypes and mAChRs in rat heart and submandibular gland. Life Sci 64:2351-8 (1999). Read more (PubMed: 10374898) »
  • Kilbinger H  et al. Comparison of affinities of muscarinic antagonists to pre- and postjunctional receptors in the guinea-pig ileum. Eur J Pharmacol 103:313-20 (1984). Read more (PubMed: 6489444) »
See all 2 Publications for this product

Customer reviews and Q&As

1-2 of 2 Q&A

Answer

Thank you for contacting us. Below are the results in water.


1033μL of HPLC grade water were added to 3.1mg of 4-DAMP to achieve a concentration of 3mg/ml and the sealed vial shaken. Some larger solid particles remained undissolved.

Ultrasonics were applied and the vial shaken. Very slight haziness was observed (almost clear).

Gentle warming was applied to approximately 30-40 OC. A clear colourless solution was formed.

Conclusion: 4-DAMP, APN07105-3-1 is soluble to 3mg/ml in water with ultrasonic assistance and gentle warming to approximately 30-40OC.




I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

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Answer

Thank you for contacting Abcam.

The units of the Ki values are nM.

We appreciate your bringing this to our attention, thanks to you the datasheet for ab120144 will be updated with the proper units

I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

Free Rabbit monoclonal antibody with any purchase of a primary antibody, while stocks last! Quote “RABMAB-XBSMG” in your next primary antibody order. For more information, visit the following link: https://www.abcam.com/index.html?pageconfig=resource&rid=15447

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