4'-Demethylepipodophyllotoxin, microtubule assembly inhibitor (ab142634)

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Overview

  • Product name

    4'-Demethylepipodophyllotoxin, microtubule assembly inhibitor

  • Description

    Potent microtubule assembly inhibitor. Antimitotic agent.

  • Biological description

    Antimitotic agent. Potent inhibitor of microtubule assembly. Antioxidant and chemopreventive effects in vivo. Orally active.

  • Purity

    > 98%

  • CAS Number

    6559-91-7

  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (5S,5aR,8aR,9R)-5-Hydroxy-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one

  • Molecular weight

    400.38

  • Molecular formula

    C21H20O8

  • PubChem identifier

    122797

  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

  • Solubility overview

    Soluble in DMSO (with warming)

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    COC1=CC(=CC(=C1O)OC)C2C3C(COC3=O)C(C4=CC5=C(C=C24)OCO5)O

  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Derry WB  et al. Synthesis and biological activity of novel thymidine derivatives of podophyllotoxin and 4'-demethylepipodophyllotoxin. Anticancer Drug Des 8:203-21 (1993). Read more (PubMed: 8517914) »
  • Pamidi CC  et al. Synthesis and biological activity of galactopyranoside derivatives of 4'-demethylepipodophyllotoxin showing VP-16 (etoposide)-like activity. Anticancer Drug Des 6:481-93 (1991). Read more (PubMed: 1764166) »
  • Loike JD  et al. Structure-activity study of the inhibition of microtubule assembly in vitro by podophyllotoxin and its congeners. Cancer Res 38:2688-93 (1978). Read more (PubMed: 679171) »

Publishing research using ab142634? Please let us know so that we can cite the reference in this datasheet.

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