Product name4-Hydroxydiclofenac, Diclofenac metabolite
DescriptionDiclofenac metabolite. COX2 inhibitor.
- [2-(2,6-Dichloro-4-hydroxy-phenylamino)phenyl]acetic acid
- 4'-Hydroxy Diclofenac
Active 4'-hydroxylated metabolite of diclofenac. Suppresses prostaglandin E2 (PGE2) formation by specifically blocking COX2 activity. Demonstrates anti-inflammatory and analgesic properties.
Chemical name2-[(2,6-Dichloro-4-hydroxyphenyl)amino]benzeneacetic acid
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO and in ethanol
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This product has been referenced in:
- Pérez S & Barceló D First evidence for occurrence of hydroxylated human metabolites of diclofenac and aceclofenac in wastewater using QqLIT-MS and QqTOF-MS. Anal Chem 80:8135-45 (2008). Read more (PubMed: 18821734) »
- Kaphalia L et al. Efficient high performance liquid chromatograph/ultraviolet method for determination of diclofenac and 4'-hydroxydiclofenac in rat serum. J Chromatogr B Analyt Technol Biomed Life Sci 830:231-7 (2006). Read more (PubMed: 16301007) »
- Yamazaki R et al. Hydrolytic activity is essential for aceclofenac to inhibit cyclooxygenase in rheumatoid synovial cells. J Pharmacol Exp Ther 289:676-81 (1999). Read more (PubMed: 10215639) »
- Yamazaki R et al. Aceclofenac blocks prostaglandin E2 production following its intracellular conversion into cyclooxygenase inhibitors. Eur J Pharmacol 329:181-7 (1997). Read more (PubMed: 9226412) »
- Sawchuk RJ et al. Analysis of diclofenac and four of its metabolites in human urine by HPLC. Pharm Res 12:756-62 (1995). Read more (PubMed: 7479564) »