4-P-PDOT, MT2 selective melatonin receptor antagonist (ab146419)

Overview

  • Product name

    4-P-PDOT, MT2 selective melatonin receptor antagonist
  • Description

    MT2 selective melatonin receptor antagonist
  • Biological description

    MT2 selective melatonin receptor antagonist (Ki values are 0.46 and 56 nM for MT2 and MT1 respectively). Counteracts melatonin-mediated ERK- and Nrf2-related antioxidant potential in vivo. Centrally active.
  • Purity

    > 99%
  • CAS Number

    134865-74-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-(1,2,3,4-Tetrahydro-4-phenyl-2-naphthalenyl)propanamide
  • Molecular weight

    279.38
  • Molecular formula

    C19H21NO
  • PubChem identifier

    3976006
  • Storage instructions

    Store at room temperature.
  • Solubility overview

    Soluble in ethanol to 100 mM and in DMSO to 100 mM
  • Handling

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCC(=O)NC1CC(C2=CC=CC=C2C1)C3=CC=CC=C3
  • Source

    Synthetic

References

This product has been referenced in:

  • Shin EJ  et al. Melatonin attenuates memory impairment induced by Klotho gene deficiency via interactive signaling between MT2 receptor, ERK, and Nrf2-related antioxidant potential. Int J Neuropsychopharmacol 18: (2015). Read more (PubMed: 25550330) »
  • Juszczak M  et al. The influence od melatonin receptors antagonists, luzindole and 4-phenyl-2-propionamidotetralin (4-P-PDOT), on melatonin-dependent vasopressin and adrenocorticotropic hormone (ACTH) release from the rat hypothalamo-hypophysial system. In vitro and in vivo studies. J Physiol Pharmacol 65:777-84 (2014). Read more (PubMed: 25554981) »
  • Wang WW  et al. Abnormal response of the proliferation and differentiation of growth plate chondrocytes to melatonin in adolescent idiopathic scoliosis. Int J Mol Sci 15:17100-14 (2014). Read more (PubMed: 25257530) »

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