Product name4mu8C, IRE1 Rnase inhibitor
DescriptionPotent, selective IRE1 Rnase inhibitor
- 4-methyl umbelliferone 8-carbaldehyde
Blocks substrate access to the active site of IRE1α. Inhibits regulated IRE1-dependent degradation (RIDD) and unconventional spicing of Xbp1 mRNA in response to endopasmic reticulum (ER) stress but has no effect on IRE1 kinase activity.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 75 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This product has been referenced in:
- Peschek J et al. A conformational RNA zipper promotes intron ejection during non-conventional XBP1 mRNA splicing. EMBO Rep 16:1688-98 (2015). Read more (PubMed: 26483401) »
- Kemp KL et al. The serine-threonine kinase inositol-requiring enzyme 1a (IRE1a) promotes IL-4 production in T helper cells. J Biol Chem 288:33272-82 (2013). Read more (PubMed: 24100031) »
- Cross BC et al. The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule. Proc Natl Acad Sci U S A 109:E869-78 (2012). Read more (PubMed: 22315414) »