Overview

  • Product name

    5-Aza-2'-deoxycytidine (Decitabine), DNMT1 inhibitor
  • Description

    Potent DNMT1 inhibitor. Induces DNA hypomethylation.
  • Alternative names

    • 5-AzadCyD
    • Dacogen
    • Decitabine
    • NSC 127716
  • Biological description

    Potent DNA methyltransferase 1 (DNMT1) inhibitor (IC50 = 0.2 μM). Incorporated into DNA, inhibits DNMT1 activity to induce DNA hypomethylation. Interferes with protein synthesis. Shows antimetabolic and anticancer activities in vitro. Active in vivo.
  • Purity

    > 99%
  • CAS Number

    2353-33-5
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Shin DY  et al. Decitabine, a DNA methyltransferase inhibitor, induces apoptosis in human leukemia cells through intracellular reactive oxygen species generation. Int J Oncol 41:910-8 (2012). Read more (PubMed: 22767021) »
  • Rodríguez-Reyes R & Morales-Ramírez P The in vivo induction of sister chromatid exchange by the demethylating agent 5-aza-2'-deoxycytidine. Mutagenesis 26:551-4 (2011). Read more (PubMed: 21454325) »
  • Liu QY  et al. Decitabine, independent of apoptosis, exerts its cytotoxic effects on cell growth in melanoma cells. Environ Toxicol Pharmacol 32:423-9 (2011). Read more (PubMed: 22004962) »
  • Cortvrindt R  et al. 5-Azacytidine and 5-aza-2'-deoxycytidine behave as different antineoplastic agents in B16 melanoma. Br J Cancer 56:261-5 (1987). Read more (PubMed: 2444244) »
See all 2 Publications for this product

Customer reviews and Q&As

Answer

We do not have stability data from our own tests. The paper at this link at least suggests that there is no degradation observed by HPLC after storage at -25oC up to 28 days, so I expect longer storage times without degradation are possible.


https://www.degruyter.com/view/j/pthp.2017.2.issue-4/pthp-2017-0025/pthp-2017-0025.xml


Storage at -80oC versus won't hurt but I don't know if it will improve stability. In general, there is less likelihood of freeze-thaw cycles occurring at -80oC compared to storage at -20oC. Freeze-thaw cycles damage some biological materials, proteins in particular, but I don't know if that's also the case for nucleoside analogs like 5-Aza-2'-deoxycytidine.

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