5'-Deoxy-5'-methylthioadenosine (Methylthioadenosine), Adenosine A1 receptor agonist (ab141257)

Overview

  • Product name

    5'-Deoxy-5'-methylthioadenosine (Methylthioadenosine), Adenosine A1 receptor agonist
  • Description

    Potent adenosine A1 receptor agonist
  • Alternative names

    • 5'-Deoxy-5'-(methylthio)adenosine
    • 5'-DEOXY-5'-METHYLTHIOADENOSINE
    • 5'-methylthioadenosine
    • Methylthioadenosine
    • MTA
    see all
  • Biological description

    Potent A1 receptor agonist (Ki = 10 μM). Also an A2 receptor antagonist and potent cAMP phosphodiesterase inhibitor (Ki = 62 μM). Regulates gene expression, proliferation, differentiation and apoptosis. Anti-inflammatory agent. Orally active. Active in vivo and in vitro.
  • Purity

    > 98%
  • CAS Number

    2457-80-9
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Kehraus S  et al. Novel amino acid derived natural products from the ascidian Atriolum robustum: identification and pharmacological characterization of a unique adenosine derivative. J Med Chem 47:2243-55 (2004). Read more (PubMed: 15084123) »
  • Avila MA  et al. Methylthioadenosine. Int J Biochem Cell Biol 36:2125-30 (2004). Read more (PubMed: 15313459) »
  • Munshi R  et al. 5'-Deoxy-5'-methylthioadenosine: a nucleoside which differentiates between adenosine receptor types. Biochem Pharmacol 37:2085-9 (1988). Read more (PubMed: 3377811) »
  • Riscoe MK  et al. Mechanism of action of 5'-methylthioadenosine in S49 cells. Biochem Pharmacol 33:3639-43 (1984). Read more (PubMed: 6095857) »

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