5-Ethynyl-2'-deoxycytidine (5-EdC), DNA synthesis monitoring probe (ab146643)

Overview

  • Product name

    5-Ethynyl-2'-deoxycytidine (5-EdC), DNA synthesis monitoring probe
  • Description

    DNA synthesis monitoring probe
  • Alternative names

    • 5-EdC
    • EdC
    • Ethynyl-labeled deoxycytidine
  • Biological description

    Relatively nontoxic 2’-deoxycytidine analog. Alternative to BrdU (5-Bromo-2’-deoxyuridine) (ab142567) for measuring de novo DNA synthesis during S-phase. Incorporates into replicating DNA instead of its natural analog thymidine.

  • Purity

    > 99%
  • CAS Number

    69075-47-4
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    251.24
  • Molecular formula

    C11H13N3O4
  • Storage instructions

    Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
  • Solubility overview

    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Ligasová A  et al. Dr Jekyll and Mr Hyde: a strange case of 5-ethynyl-2'-deoxyuridine and 5-ethynyl-2'-deoxycytidine. Open Biol 6:150172 (2016). Read more (PubMed: 26740587) »
  • Qu D  et al. 5-Ethynyl-2'-deoxycytidine as a new agent for DNA labeling: detection of proliferating cells. Anal Biochem 417:112-21 (2011). Read more (PubMed: 21683679) »
  • Guan L  et al. Intracellular detection of cytosine incorporation in genomic DNA by using 5-ethynyl-2'-deoxycytidine. Chembiochem 12:2184-90 (2011). Read more (PubMed: 21805552) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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