Overview

  • Product name

    5-Fluorouracil, RNA and DNA synthesis inhibitor
  • Description

    RNA and DNA synthesis inhibitor. Anticancer agent.
  • Biological description

    RNA and DNA synthesis inhibitor. Anticancer agent. Pyrimidine analog causing misincorporation of fluoronucleotides into DNA/RNA during synthesis. Thymidylate synthase inhibitor. Induces cell cycle arrest G1/S and apoptosis. Orally active.
  • Purity

    > 98%
  • CAS Number

    51-21-8
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Cao Z  et al. Enhancement of antitumor activity of low-dose 5-fluorouracil by combination with Fuzheng-Yiliu granules in hepatoma 22 tumor-bearing mice. Integr Cancer Ther 12:174-81 (2013). Read more (PubMed: 22791308) »
  • Tsai CC  et al. Biodistribution and pharmacokinetics of 188Re-liposomes and their comparative therapeutic efficacy with 5-fluorouracil in C26 colonic peritoneal carcinomatosis mice. Int J Nanomedicine 6:2607-19 (2011). Read more (PubMed: 22114492) »
  • Matuo R  et al. 5-Fluorouracil and its active metabolite FdUMP cause DNA damage in human SW620 colon adenocarcinoma cell line. J Appl Toxicol 29:308-16 (2009). Read more (PubMed: 19115314) »
See 1 Publication for this product

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