5-hmC (5-Hydroxymethylcytosine), DNA pyrimidine nitrogen base (ab146141)

Overview

  • Product name

    5-hmC (5-Hydroxymethylcytosine), DNA pyrimidine nitrogen base
  • Description

    Novel DNA pyrimidine nitrogen base
  • Biological description

    Novel DNA pyrimidine nitrogen base. Initiates DNA demethylation. 5-Methylcytosine (ab145606) oxidation product. Epigenetic modifier in vivo.
  • CAS Number

    1123-95-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    6-Amino-5-(hydroxymethyl)-1H-pyrimidin-2-one
  • Molecular weight

    141.13
  • Molecular formula

    C5H7N3O2
  • PubChem identifier

    70751
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=NC(=O)NC(=C1CO)N
  • Source

    Synthetic

References

This product has been referenced in:

  • Ficz G New insights into mechanisms that regulate DNA methylation patterning. J Exp Biol 218:14-20 (2015). Read more (PubMed: 25568447) »
  • Guo JU  et al. Genome-wide antagonism between 5-hydroxymethylcytosine and DNA methylation in the adult mouse brain. Front Biol (Beijing) 9:66-74 (2014). Read more (PubMed: 25568643) »
  • Tahiliani M  et al. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science 324:930-5 (2009). Read more (PubMed: 19372391) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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