Overview

  • Product name

    5-Iodo A85380 dihydrochloride, alpha4beta2 and alpha6beta2 receptor agonist
  • Description

    Potent α4β2 and α6β2 receptor agonist
  • Biological description

    Potent α4β2 and α6β2 receptor agonist (Ki = 0.2 nM at α4β2). 850 and 27000-fold more potent at α4β2 than α3β4 and α7, respectively. Shows antidepressant effects. Active in vivo.
  • Purity

    > 98%
  • CAS Number

    1217837-17-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-[(2S)-2-Azetidinylmethoxy]-5-iodopyridine dihydrochloride
  • Molecular weight

    363.03
  • Molecular formula

    C9H11IN2O.2HCl
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM and DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    Cl.Cl.Ic1cc(cnc1)OC[C@@H]2CCN2
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Caldarone BJ  et al. Dissociation between duration of action in the forced swim test in mice and nicotinic acetylcholine receptor occupancy with sazetidine, varenicline, and 5-I-A85380. Psychopharmacology (Berl) 217:199-210 (2011). Read more (PubMed: 21487659) »
  • Mogg AJ  et al. Functional responses and subunit composition of presynaptic nicotinic receptor subtypes explored using the novel agonist 5-iodo-A-85380. Neuropharmacology 47:848-59 (2004). Read more (PubMed: 15527819) »
  • Mukhin AG  et al. 5-Iodo-A-85380, an alpha4beta2 subtype-selective ligand for nicotinic acetylcholine receptors. Mol Pharmacol 57:642-9 (2000). Read more (PubMed: 10692507) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab120599.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up