5-Oxoete (5-Ketoeicosa-6E,8Z,11Z,14E-tetraenoic acid), Oxoeicosanoid (OXE) receptor agonist (ab141669)

Overview

  • Product name

    5-Oxoete (5-Ketoeicosa-6E,8Z,11Z,14E-tetraenoic acid), Oxoeicosanoid (OXE) receptor agonist
  • Description

    Oxoeicosanoid (OXE) receptor agonist. Chemoattractant for neutrophils and eosinophils.
  • Alternative names

    • 5-KETE
    • 5-Oxoete
  • Biological description

    Potent oxoeicosanoid (OXE) receptor agonist (EC50 = 0.33 nM). Potent chemoattractant for neutrophils and eosinophils. Induces a variety of rapid responses in neutrophils and eosinophils, including calcium mobilization, actin polymerization, CD11b expression, and L-selectin shedding.
  • Purity

    > 95%
  • CAS Number

    106154-18-1
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Grant GE  et al. 5-Oxo-ETE and the OXE receptor. Prostaglandins Other Lipid Mediat 89:98-104 (2009). Read more (PubMed: 19450703) »
  • Patel P  et al. Structural requirements for activation of the 5-oxo-6E,8Z, 11Z,14Z-eicosatetraenoic acid (5-oxo-ETE) receptor: identification of a mead acid metabolite with potent agonist activity. J Pharmacol Exp Ther 325:698-707 (2008). Read more (PubMed: 18292294) »
  • Jones CE  et al. Expression and characterization of a 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid receptor highly expressed on human eosinophils and neutrophils. Mol Pharmacol 63:471-7 (2003). Read more (PubMed: 12606753) »

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