Key features and details
- Potent, selective, cell-permeable STAT3 inhibitor
- CAS Number: 22112-89-6
- Purity: > 98%
- Soluble in chloroform
- Form / State: Solid
- Source: Synthetic
Product name5,15-DPP (Stat3 Inhibitor VIII), STAT3 inhibitor
DescriptionPotent, selective, cell-permeable STAT3 inhibitor
Potent, selective, cell-permeable STAT3 inhibitor (Kd = 880 nM). Inhibits STAT3 dimerization (IC50 values are 0.28 and 10 μM for STAT3 SH2 domain-mediated ligand binding and STAT1 ligand binding, respectively). Blocks TRAIL-induced invasion.
Storage instructionsStore at +4°C. It is important to note that this product is reported to be light sensitive. Store In the Dark.
Solubility overviewSoluble in chloroform
Solvents listed may be unsuitable for use in biological experiments. These solvents are intended to enable solubilisation and mixing of components. We recommend that biologically unsuitable solvents are removed prior to solubilisation in experimental media.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab146023 has not yet been referenced specifically in any publications.