5,6-Dehydrokawain, PAF receptor binding inhibitor (ab142508)

Overview

  • Product name

    5,6-Dehydrokawain, PAF receptor binding inhibitor
  • Description

    Potent PAF receptor binding inhibitor
  • Biological description

    Potent Platelet-activating factor (PAF) receptor binding inhibitor (IC50= 59.3 μM). Active in vitro.
  • Purity

    > 98%
  • CAS Number

    15345-89-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-Methoxy-6-[(E)-2-phenylethenyl]pyran-2-one

  • Molecular weight

    228.25
  • Molecular formula

    C14H12O3
  • PubChem identifier

    5273621
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    COC1=CC(=O)OC(=C1)C=CC2=CC=CC=C2
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Li Y  et al. Methysticin and 7,8-dihydromethysticin are two major kavalactones in kava extract to induce CYP1A1. Toxicol Sci 124:388-99 (2011). Read more (PubMed: 21908763) »
  • Jantan I  et al. Inhibitory effects of compounds from Zingiberaceae species on platelet activating factor receptor binding. Phytother Res 18:1005-7 (2004). Read more (PubMed: 15742349) »
  • Hsu SY  et al. Toxicologic studies of dihydro-5,6-dehydrokawain and 5,6-dehydrokawain. Planta Med 60:88-90 (1994). Read more (PubMed: 8134424) »
  • Teng CM  et al. Antiplatelet action of dehydrokawain derivatives isolated from Alpinia speciosa rhizoma. Chin J Physiol 33:41-8 (1990). Read more (PubMed: 2376215) »

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