5,8,11,14-Eicosatetraynoic acid, Arachidonic acid uptake inhibitor (ab141597)

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Overview

  • Product name

    5,8,11,14-Eicosatetraynoic acid, Arachidonic acid uptake inhibitor

  • Description

    Arachidonic acid uptake inhibitor

  • Biological description

    Arachidonic acid uptake inhibitor. Inhibits cyclooxygenase (ID50=8 µM) and lipoxygenases 5-, 12- and 15- (ID50=10, 0.3, and 0.2 µM respectively). Active in vivo and in vitro.

  • Purity

    > 98%

  • CAS Number

    1191-85-1

  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    Icosa-5,8,11,14-tetraynoic acid

  • Molecular weight

    296.50

  • Molecular formula

    C20H24O2

  • PubChem identifier

    1780

  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.

  • Solubility overview

    Soluble in ethanol and DMSO

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCCCCC#CCC#CCC#CCC#CCCCC(=O)O

  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Lee JH  et al. 5, 8, 11, 14-eicosatetraynoic acid suppresses CCL2/MCP-1 expression in IFN-?-stimulated astrocytes by increasing MAPK phosphatase-1 mRNA stability. J Neuroinflammation 9:34 (2012). Read more (PubMed: 22339770) »
  • Bolle P  et al. Response to isoprenaline of rabbit detrusor muscle following exposure to 5, 8, 11, 14 eicosatetraynoic acid. Role of prostanoids on beta-adrenergic-evoked response. J Auton Pharmacol 19:161-5 (1999). Read more (PubMed: 10511472) »
  • Richards KM & Marnett LJ Leukocyte 12-lipoxygenase: expression, purification, and investigation of the role of methionine residues in turnover-dependent inactivation and 5,8,11,14-eicosatetraynoic acid inhibition. Biochemistry 36:6692-9 (1997). Read more (PubMed: 9184149) »

Publishing research using ab141597? Please let us know so that we can cite the reference in this datasheet.

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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