Overview

  • Product name

    Anti-5HT3B receptor antibody
    See all 5HT3B receptor primary antibodies
  • Description

    Goat polyclonal to 5HT3B receptor
  • Host species

    Goat
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Rat
  • Immunogen

    Synthetic peptide:

    C-QEDIENDKRSFLND

    , corresponding to internal sequence amino acids 187-200 of Rat 5HT3B receptor (NP_071525.1)

  • Positive control

    • Rat brain lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab115023 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.03 - 0.1 µg/ml. Detects a band of approximately 50 kDa (predicted molecular weight: 50 kDa).

Target

  • Function

    This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.
  • Tissue specificity

    Expressed in the brain cortex, in the caudate nucleus, the hyppocampus, the thalamus and the amygdala. Detected in the kidney and testis as well as in monocytes of the spleen, small and large intestine, uterus, prostate, ovary and placenta.
  • Sequence similarities

    Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3B sub-subfamily.
  • Post-translational
    modifications

    N-glycosylation required for membrane localization.
  • Cellular localization

    Cell membrane. Presumably retained within the endoplasmic reticulum unless complexed with HTR3A.
  • Information by UniProt
  • Database links

  • Alternative names

    • 5 HT3 B antibody
    • 5 HT3B antibody
    • 5 HTR3B antibody
    • 5 hydroxytryptamine 3 receptor B subunit antibody
    • 5 hydroxytryptamine receptor 3B antibody
    • 5 hydroxytryptamine serotonin receptor 3B antibody
    • 5-HT3-B antibody
    • 5-HT3B antibody
    • 5-hydroxytryptamine receptor 3B antibody
    • 5HT3B_HUMAN antibody
    • 5HTR3B antibody
    • Htr3b antibody
    • Serotonin gated ion channel subunit antibody
    • Serotonin receptor 3B antibody
    see all

Images

  • Anti-5HT3B receptor antibody (ab115023) at 0.1 µg/ml + Rat brain lysate (in RIPA buffer) at 35 µg

    Developed using the ECL technique.

    Predicted band size: 50 kDa



    Primary incubation: 1 hour

References

This product has been referenced in:

  • Li F  et al. Shuyu Capsules Relieve Premenstrual Syndrome Depression by Reducing 5-HT3AR and 5-HT3BR Expression in the Rat Brain. Neural Plast 2016:7950781 (2016). Read more (PubMed: 27725889) »
See 1 Publication for this product

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