Key features and details
- Goat polyclonal to 5HT3B receptor
- Suitable for: WB
- Reacts with: Rat
- Isotype: IgG
Product nameAnti-5HT3B receptor antibody
See all 5HT3B receptor primary antibodies
DescriptionGoat polyclonal to 5HT3B receptor
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Rat
- Rat brain lysate.
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
Storage bufferpH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 0.5% BSA, 99% Tris buffered saline
Concentration information loading...
PurityImmunogen affinity purified
Purification notesab115023 was purified from Goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Our Abpromise guarantee covers the use of ab115023 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 0.03 - 0.1 µg/ml. Detects a band of approximately 50 kDa (predicted molecular weight: 50 kDa).
1 hour primary incubation is recommended for this product.
FunctionThis is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.
Tissue specificityExpressed in the brain cortex, in the caudate nucleus, the hyppocampus, the thalamus and the amygdala. Detected in the kidney and testis as well as in monocytes of the spleen, small and large intestine, uterus, prostate, ovary and placenta.
Sequence similaritiesBelongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3B sub-subfamily.
modificationsN-glycosylation required for membrane localization.
Cellular localizationCell membrane. Presumably retained within the endoplasmic reticulum unless complexed with HTR3A.
- Information by UniProt
- 5 HT3 B antibody
- 5 HT3B antibody
- 5 HTR3B antibody
ab115023 has been referenced in 1 publication.
- Li F et al. Shuyu Capsules Relieve Premenstrual Syndrome Depression by Reducing 5-HT3AR and 5-HT3BR Expression in the Rat Brain. Neural Plast 2016:7950781 (2016). PubMed: 27725889