Overview

  • Product name

    Anti-5HT4 Receptor antibody
    See all 5HT4 Receptor primary antibodies
  • Description

    Rabbit polyclonal to 5HT4 Receptor
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Guinea pig, Hamster, Cow, Dog, Pig, Gorilla
  • Immunogen

    Synthetic peptide corresponding to Human 5HT4 Receptor. (A 15 amino acid peptide from the 3rd cytoplasmic domain).
    Database link: Q13639

  • Positive control

    • Human brain, medulla tissue; Human brain, glioblastoma tissue; Human skin, Melanoma tissue; Human prostate tissue; Human kidney tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab219116 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 15 - 20 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Relevance

    The 5HT4 Receptor is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulates adenylate cyclase. 5HT4a receptors may play a role in opioid-induced respiratory depression.
  • Cellular localization

    Cell membrane; Multi-pass membrane protein. Endosome. Note: Interaction with SNX27 mediates recruitment to early endosomes, while interaction with SLC9A3R1 and EZR might target the protein to specialized subcellular regions, such as microvilli.
  • Database links

  • Alternative names

    • 5 HT 4 antibody
    • 5 HT4 antibody
    • 5 HT4R antibody
    • 5 hydroxytryptamine (serotonin) receptor 4, G protein coupled antibody
    • 5 hydroxytryptamine 4 receptor antibody
    • 5 hydroxytryptamine receptor 4 antibody
    • 5 hydroxytryptamine serotonin receptor 4 antibody
    • 5 hydroxytryptamine4 receptor antibody
    • 5-HT-4 antibody
    • 5-ht4 antibody
    • 5-HT4R antibody
    • 5H4 antibody
    • 5HT 4 antibody
    • 5HT4 antibody
    • 5ht4 receptor antibody
    • 5HT4R antibody
    • Cardiac 5 HT4 receptor antibody
    • HTR 4 antibody
    • HTR4 antibody
    • serotonin 4 receptor antibody
    • Serotonin 5 HT4 receptor antibody
    • serotonin 5-ht-4 receptor antibody
    • serotonin 5-ht-4a antibody
    • Serotonin receptor 4 antibody
    see all

Images

  • Immunohistochemical analysis of formalin fixed, paraffin embedded Human brain (medulla) tissue labeling 5HT4 with ab219116 at 20 µg/ml.

  • Immunohistochemical analysis of formalin fixed, paraffin embedded Human brain (glioblastoma) tissue labeling 5HT4 with ab219116 at 20 µg/ml.

  • Immunohistochemical analysis of formalin fixed, paraffin embedded Human skin (melonoma) tissue labeling 5HT4 with ab219116 at 20 µg/ml.

  • Immunohistochemical analysis of formalin fixed, paraffin embedded Human prostate tissue labeling 5HT4 with ab219116 at 20 µg/ml.

  • Immunohistochemical analysis of formalin fixed, paraffin embedded Human kidney tissue labeling 5HT4 with ab219116 at 20 µg/ml.

References

ab219116 has not yet been referenced specifically in any publications.

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