Overview

  • Product name

    Anti-5HT7 Receptor antibody - N-terminal
    See all 5HT7 Receptor primary antibodies
  • Description

    Rabbit polyclonal to 5HT7 Receptor - N-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, ICC/IFmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide corresponding to a region within N terminal amino acids 1-45 of Human 5HT7 Receptor (Uniprot ID: P34969).

  • Positive control

    • A549, HeLa, Jurkat and NT2D1 whole cell lysates; HeLa cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab137493 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 54 kDa.
ICC/IF 1/100 - 1/1000.

Target

  • Function

    This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.
  • Tissue specificity

    Isoform A is the predominant isoform in spleen, caudate and hippocampus. Isoform B is expressed at lower levels. Isoform D is a minor isoform in term of expression.
  • Sequence similarities

    Belongs to the G-protein coupled receptor 1 family.
  • Cellular localization

    Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • 5 HT 7 antibody
    • 5 HT X antibody
    • 5 hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase coupled) antibody
    • 5 hydroxytryptamine (serotonin) receptor 7 antibody
    • 5 hydroxytryptamine receptor 7 antibody
    • 5-HT-7 antibody
    • 5-HT-X antibody
    • 5-HT7 antibody
    • 5-hydroxytryptamine receptor 7 antibody
    • 5HT7 antibody
    • 5HT7R_HUMAN antibody
    • htr7 antibody
    • Serotonin 5 HT 7 receptor antibody
    • Serotonin receptor 7 antibody
    see all

Images

  • Anti-5HT7 Receptor antibody - N-terminal (ab137493) at 1/1000 dilution + Jurkat whole cell lysate at 30 µg

    Predicted band size: 54 kDa



    10% SDS PAGE
  • Immunofluorescence analysis of methanol-fixed HeLa cells, labelling 5HT7 Receptor with ab137493 at 1/200 dilution. The lower image is co-stained with Hoechst 33342.

References

This product has been referenced in:

  • Zhu H  et al. MiRNA-29a modulates visceral hyperalgesia in irritable bowel syndrome by targeting HTR7. Biochem Biophys Res Commun 511:671-678 (2019). Read more (PubMed: 30827505) »
See 1 Publication for this product

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