5(S),12(S)-Dihydroxyeicosa-6E,8E,10E,14Z-tetraenoic acid (6-trans-12-epi-LTB4) (ab141535)

Overview

  • Product name
    5(S),12(S)-Dihydroxyeicosa-6E,8E,10E,14Z-tetraenoic acid (6-trans-12-epi-LTB4)
  • Description
    Potent eicosanoid lipid mediator. Arachidonic acid metabolite.
  • Alternative names
    • 6-trans-12-epi-Leukotriene B4
    • 6-trans-12-epi-LTB4
  • Biological description
    Potent eicosanoid lipid mediator. Arachidonic acid metabolite. Weak chemotactic agent (compared to LTB4) and impotent aggregate on human polymorphonuclear leukocytes.
  • Purity
    > 99%

Properties

References

This product has been referenced in:
  • Strömberg F & Haeggström JZ Enzymatic conversion of leukotriene A4 into 5(S),12(R)-diHETE in frog tissues. Adv Exp Med Biol 407:555-9 (1997). Read more (PubMed: 9322007) »
  • Lee TH  et al. Characterization and biologic properties of 5,12-dihydroxy derivatives of eicosapentaenoic acid, including leukotriene B5 and the double lipoxygenase product. J Biol Chem 259:2383-9 (1984). Read more (PubMed: 6321468) »
  • Borgeat P & Samuelsson B Metabolism of arachidonic acid in polymorphonuclear leukocytes. Structural analysis of novel hydroxylated compounds. J Biol Chem 254:7865-9 (1979). Read more (PubMed: 468794) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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