Product name6-(Dimethylamino)purine, Puromycin analog
DescriptionA puromycin analog that acts as a protein kinase inhibitor.
Puromycin analog. Protein kinase and cyclin-dependent kinase inhibitor used in parthenogenesis and meiosis studies. Reversible inhibitor of the transition to metaphase during the first meiotic cell division of mouse oocytes.
Storage instructionsStore at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This product has been referenced in:
- Katoh M et al. 6-Dimethylaminopurine (6-DMAP), which is used to produce most cloned animals, is mutagenic in Salmonella typhimurium TA1535. Mutat Res 560:199-201 (2004). Read more (PubMed: 15157657) »
- De Azevedo WF et al. Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine. Eur J Biochem 243:518-26 (1997). Read more (PubMed: 9030780) »
- Szöllösi MS et al. Inhibition of protein kinases by 6-dimethylaminopurine accelerates the transition to interphase in activated mouse oocytes. J Cell Sci 104 ( Pt 3):861-72 (1993). Read more (PubMed: 8391012) »
- Rime H et al. 6-Dimethylaminopurine (6-DMAP), a reversible inhibitor of the transition to metaphase during the first meiotic cell division of the mouse oocyte. Dev Biol 133:169-79 (1989). Read more (PubMed: 2540051) »