Overview

  • Product name

    6-ECDCA (INT-747), FXR agonist
  • Description

    Potent and selective FXR agonist
  • Biological description

    Potent and selective FXR agonist (EC50 = 99 nM). Dual FXR/GP-BAR1 ligand. Induces preadiopocyte differentiation. Induces apoptosis. Shows anticholeretic and anti-inflammatory effects and regulates adipose cell function in vivo. Orally active.
  • Purity

    > 95%
  • CAS Number

    459789-99-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (4R)-4-[(3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-Ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
  • Molecular weight

    420.63
  • Molecular formula

    C26H44O4
  • PubChem identifier

    447715
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 50 mM and in DMSO to 75 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC[C@@H]1[C@@H]2C[C@@H](CC[C@@]2([C@H]3CC[C@]4([C@H]([C@@H]3[C@@H]1O)CC[C@@H]4[C@H](C)CCC(=O)O)C)C)O
  • Source

    Synthetic

References

This product has been referenced in:

  • Fiorucci S  et al. Targeting FXR in cholestasis: hype or hope. Expert Opin Ther Targets :1-11 (2014). Read more (PubMed: 25200104) »
  • Ghebremariam YT  et al. FXR agonist INT-747 upregulates DDAH expression and enhances insulin sensitivity in high-salt fed Dahl rats. PLoS One 8:e60653 (2013). Read more (PubMed: 23593273) »
  • Baghdasaryan A  et al. Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2-/- (Abcb4-/-) mouse cholangiopathy model by promoting biliary HCO?3 output. Hepatology 54:1303-12 (2011). Read more (PubMed: 22006858) »
See 1 Publication for this product

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