Key features and details
- High affinity aryl hydrocarbon receptor ligand
- CAS Number: 172922-91-7
- Purity: > 95%
- Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Product name6-Formylindolo(3,2-b)carbazole, Aryl hydrocarbon receptor ligand
DescriptionHigh affinity aryl hydrocarbon receptor ligand
Biological descriptionHigh affinity aryl hydrocarbon receptor ligand. Proposed endogenous AhR ligand.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 25 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
2D chemical structure image of ab141631, 6-Formylindolo(3,2-b)carbazole, Aryl hydrocarbon receptor ligand
FICZ upregulates Cyp1A1 expression.
HL-60 cells were initiated in culture at 0.1 x 106 cells/ml with 1 μM RA, 100 nM FICZ, 1 μM α-NF as indicated for 2 h and 48 h. At 2 h post treatment, FICZ upregulates Cyp1A1 expression in HL-60 cells, reaching significance for RA+FICZ vs C (p = 0.0029) and vs RA (p = 0.0045) and α-NF+FICZ+RA vs C (p = 0.0086) and vs RA (p = 0.0134).
FICZ = 6-Formylindolo(3,2-b)carbazole, Aryl hydrocarbon receptor ligand.
(From Figure 4 of Bunaciu et al).
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab141631 has been referenced in 2 publications.
- Bunaciu RP et al. Retinoic acid and 6-formylindolo(3,2-b)carbazole (FICZ) combination therapy reveals putative targets for enhancing response in non-APL AML. Leuk Lymphoma 60:1697-1708 (2019). PubMed: 30570341
- Bunaciu RP et al. 6-Formylindolo(3,2-b)Carbazole (FICZ) Modulates the Signalsome Responsible for RA-Induced Differentiation of HL-60 Myeloblastic Leukemia Cells. PLoS One 10:e0135668 (2015). PubMed: 26287494