6-Thio-GTP (aqueous solution) (Thiogtp), Vac-1-Rac signaling inhibitor (ab146746)

Overview

  • Product name

    6-Thio-GTP (aqueous solution) (Thiogtp), Vac-1-Rac signaling inhibitor
  • Description

    Vac-1-Rac signaling inhibitor
  • Alternative names

    • Thiogtp
  • Biological description

    Vac-1-Rac signaling inhibitor. Azathioprine (ab143064) metabolite. 6-mercaptopurine (ab142389) derivative. Inhibits TNF-α-induced downstream signaling via JNK. Reduces c-Jun, transcription factor-2 and NF-κB activation. Shows immunosuppressant effects.
  • Purity

    > 95%
  • CAS Number

    17670-19-8
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    539.24
  • Molecular formula

    C10H16N5O13P3S
  • Storage instructions

    Store at -20°C (desiccating conditions).
  • Solubility overview

    Supplied in water (10 mM)
  • Handling

    Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Marinkovic G  et al. Inhibition of GTPase Rac1 in endothelium by 6-mercaptopurine results in immunosuppression in nonimmune cells: new target for an old drug. J Immunol 192:4370-8 (2014). Read more (PubMed: 24670805) »
  • Karner S  et al. Determination of 6-thioguanosine diphosphate and triphosphate and nucleoside diphosphate kinase activity in erythrocytes: novel targets for thiopurine therapy? Ther Drug Monit 32:119-28 (2010). Read more (PubMed: 20216118) »
  • Poppe D  et al. Azathioprine suppresses ezrin-radixin-moesin-dependent T cell-APC conjugation through inhibition of Vav guanosine exchange activity on Rac proteins. J Immunol 176:640-51 (2006). Read more (PubMed: 16365460) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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