Overview

  • Product name

    6-Thioguanine, Antimetabolite
  • Description

    Antimetabolite. Guanine analog.
  • Biological description

    Antimetabolite. Guanine analogue. Incorporates into mitochondrial DNA and induces DNA double-strand breaks. Antitumor, immunosuppressive and anti-inflammatory effects in vivo. Metabolite of Azathioprine (ab143064). Orally active.
  • Purity

    > 90%
  • CAS Number

    154-42-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-Amino-3,7-dihydropurine-6-thione
  • Molecular weight

    167.19
  • Molecular formula

    C5H5N5S
  • PubChem identifier

    2723601
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=NC2=C(N1)C(=S)N=C(N2)N
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Benedict AL  et al. The indirect antioxidant sulforaphane protects against thiopurine-mediated photooxidative stress. Carcinogenesis 33:2457-66 (2012). Read more (PubMed: 22983983) »
  • Daehn I  et al. 6-Thioguanine damages mitochondrial DNA and causes mitochondrial dysfunction in human cells. FEBS Lett 585:3941-6 (2011). Read more (PubMed: 22062154) »
  • Issaeva N  et al. 6-thioguanine selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance. Cancer Res 70:6268-76 (2010). Read more (PubMed: 20631063) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab142729.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up