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Cardiovascular Angiogenesis Adhesion / ECM Extracellular Matrix
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Anti-67kDa Laminin Receptor antibody (ab110499)

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Western blot - Anti-67kDa Laminin Receptor antibody (ab110499)

    Key features and details

    • Rabbit polyclonal to 67kDa Laminin Receptor
    • Suitable for: WB
    • Reacts with: Human
    • Isotype: IgG

    You may also be interested in

    Protein
    Product image
    Recombinant Human 67kDa Laminin Receptor protein (ab114294)
    Secondary
    Product image
    Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

    View more associated products

    Overview

    • Product name

      Anti-67kDa Laminin Receptor antibody
      See all 67kDa Laminin Receptor primary antibodies
    • Description

      Rabbit polyclonal to 67kDa Laminin Receptor
    • Host species

      Rabbit
    • Tested applications

      Suitable for: WBmore details
    • Species reactivity

      Reacts with: Human
      Predicted to work with: Mouse, Rat, Sheep, Chicken, Cow, Pig, Zebrafish, Zebra finch
    • Immunogen

      Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.

    • Positive control

      • Recombinant Human 67kDa Laminin Receptor protein (ab114294) can be used as a positive control in WB. This antibody gave a positive signal in the following whole cell lysates: Caco2; HCT116; LOVO; A549; HeLa.
    • General notes

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
    • Storage buffer

      Preservative: 0.02% Sodium azide
      Constituent: PBS
    • Concentration information loading...
    • Purity

      Immunogen affinity purified
    • Clonality

      Polyclonal
    • Isotype

      IgG
    • Research areas

      • Cardiovascular
      • Angiogenesis
      • Adhesion / ECM
      • Extracellular Matrix
      • Neuroscience
      • Neurology process
      • Neurodegenerative disease
      • Prions
      • Neuroscience
      • Cell Adhesion Proteins
      • Cytoskeletal Proteins
      • Intermediate Filaments
      • Signal Transduction
      • Cytoskeleton / ECM
      • Basal Lamina
      • Neuroscience
      • Cell Adhesion Proteins
      • ECM Proteins

    Associated products

    • Compatible Secondaries

      • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
      • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
    • Isotype control

      • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
    • Positive Controls

      • Recombinant Human 67kDa Laminin Receptor protein (ab114294)
    • Recombinant Protein

      • Recombinant Human 67kDa Laminin Receptor protein (ab114294)

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab110499 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    WB
    Use a concentration of 1 µg/ml. Detects a band of approximately 37 kDa (predicted molecular weight: 33 kDa).
    Notes
    WB
    Use a concentration of 1 µg/ml. Detects a band of approximately 37 kDa (predicted molecular weight: 33 kDa).

    Target

    • Function

      Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria.
    • Sequence similarities

      Belongs to the ribosomal protein S2P family.
    • Post-translational
      modifications

      Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
      Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
    • Cellular localization

      Cell membrane. Cytoplasm. Nucleus. 67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus (By similarity). Co-localizes with PPP1R16B in the cell membrane.
    • Target information above from: UniProt accession P08865 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 281898 Cow
      • Entrez Gene: 3921 Human
      • Entrez Gene: 100505031 Mouse
      • Entrez Gene: 16785 Mouse
      • Entrez Gene: 641351 Pig
      • Entrez Gene: 29236 Rat
      • Entrez Gene: 394027 Zebrafish
      • Omim: 150370 Human
      • SwissProt: P26452 Cow
      • SwissProt: P08865 Human
      • SwissProt: P14206 Mouse
      • SwissProt: Q4GWZ2 Pig
      • SwissProt: P38983 Rat
      • SwissProt: Q803F6 Zebrafish
      • Unigene: 449909 Human
      • Unigene: 311972 Mouse
      • Unigene: 391708 Mouse
      • Unigene: 4071 Mouse
      • Unigene: 121972 Rat
      • Unigene: 161973 Rat
      • Unigene: 999 Rat
      • Unigene: 75127 Zebrafish
      see all
    • Alternative names

      • 34/67 kDa laminin receptor antibody
      • 37 kDa laminin receptor precursor antibody
      • 37/67 kDa laminin receptor antibody
      • 37LRP antibody
      • 40S ribosomal protein SA antibody
      • 67 kDa laminin receptor antibody
      • 67LR antibody
      • Colon carcinoma laminin binding protein antibody
      • Colon carcinoma laminin-binding protein antibody
      • LAMBR antibody
      • Laminin receptor 1 antibody
      • Laminin-binding protein precursor p40 antibody
      • LAMR 1 antibody
      • LamR antibody
      • LAMR1 antibody
      • LBP antibody
      • LBP/p40 antibody
      • LRP antibody
      • LRP/LR antibody
      • Multidrug resistance associated protein MGr1 Ag antibody
      • Multidrug resistance associated protein MGr1Ag antibody
      • Multidrug resistance-associated protein MGr1-Ag antibody
      • NEM/1CHD4 antibody
      • p40 antibody
      • Ribosomal Protein SA antibody
      • rpsA antibody
      • RSSA_HUMAN antibody
      • SA antibody
      see all

    Images

    • Western blot - Anti-67kDa Laminin Receptor antibody (ab110499)
      Western blot - Anti-67kDa Laminin Receptor antibody (ab110499)
      All lanes : Anti-67kDa Laminin Receptor antibody (ab110499) at 1 µg/ml

      Lane 1 : Caco 2 (Human colonic carcinoma cell line) Whole Cell Lysate
      Lane 2 : HCT 116 (Human Colorectal Carcinoma) Whole Cell Lysate
      Lane 3 : LOVO (Human colon adenocarcinoma cell line) Whole Cell Lysate
      Lane 4 : A549 (Human lung adenocarcinoma epithelial cell line) Whole Cell Lysate
      Lane 5 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution

      Developed using the ECL technique.

      Performed under reducing conditions.

      Predicted band size: 33 kDa
      Observed band size: 37 kDa why is the actual band size different from the predicted?
      Additional bands at: 19 kDa, 94 kDa. We are unsure as to the identity of these extra bands.


      Exposure time: 30 seconds

    Protocols

    • Western blot protocols

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    References (0)

    Publishing research using ab110499? Please let us know so that we can cite the reference in this datasheet.

    ab110499 has not yet been referenced specifically in any publications.

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