Key features and details
- Rabbit polyclonal to 67kDa Laminin Receptor
- Suitable for: WB, IHC-P
- Reacts with: Zebrafish
- Isotype: IgG
Product nameAnti-67kDa Laminin Receptor antibody
See all 67kDa Laminin Receptor primary antibodies
DescriptionRabbit polyclonal to 67kDa Laminin Receptor
Tested applicationsSuitable for: WB, IHC-Pmore details
Species reactivityReacts with: Zebrafish
Full length protein corresponding to Human 67kDa Laminin Receptor.
Database link: Q803F6
- WB: Whole zebrafish and zebrafish eye tissues. IHC-P: Zebrafish tissue.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle.
Storage bufferpH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 10% Glycerol (glycerin, glycerine)
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab229575 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/3000. Predicted molecular weight: 34 kDa.|
|IHC-P||1/100 - 1/1000.|
FunctionRequired for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria.
Sequence similaritiesBelongs to the ribosomal protein S2P family.
modificationsAcylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
Cellular localizationCell membrane. Cytoplasm. Nucleus. 67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus (By similarity). Co-localizes with PPP1R16B in the cell membrane.
- Information by UniProt
- 34/67 kDa laminin receptor antibody
- 37 kDa laminin receptor precursor antibody
- 37/67 kDa laminin receptor antibody
All lanes : Anti-67kDa Laminin Receptor antibody (ab229575) at 1/1000 dilution
Lane 1 : Whole zebrafish tissue
Lane 2 : Zebrafish eye tissue
Lysates/proteins at 30 µg per lane.
Predicted band size: 34 kDa
12% SDS-PAGE gel.
Paraffin-embedded zebrafish tissue stained for 67kDa Laminin Receptor using ab229575 at 1/300 dilution in immunohistochemical analysis.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab229575 has not yet been referenced specifically in any publications.