Overview

  • Product name

    680C91, tryptophan 2,3-dioxygenase inhibitor
  • Description

    Potent, selective, substrate competitive tryptophan 2,3-dioxygenase inhibitor
  • Biological description

    Potent, selective, substrate competitive tryptophan 2,3-dioxygenase inhibitor (Ki = 51 nM). Inhibits tryptophan catabolism. Increases brain tryptophan and serotonin levels in vivo.
  • CAS Number

    163239-22-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    6-Fluoro-3-[(E)-2-pyridin-3-ylethenyl]-1H-indole
  • Molecular weight

    238.26
  • Molecular formula

    C15H11FN2
  • PubChem identifier

    10014426
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 50 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC(=CN=C1)/C=C/C2=CNC3=C2C=CC(=C3)F
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Salter M  et al. The effects of a selective inhibitor of tryptophan 2,3-dioxygenase and a combined inhibitor of tryptophan 2,3-dioxygenase and 5-HT reuptake on serotonergic function in the rat. Adv Exp Med Biol 398:61-5 (1996). Read more (PubMed: 8906241) »
  • Salter M  et al. The effects of a novel and selective inhibitor of tryptophan 2,3-dioxygenase on tryptophan and serotonin metabolism in the rat. Biochem Pharmacol 49:1435-42 (1995). Read more (PubMed: 7539265) »
  • Salter M  et al. The effects of an inhibitor of tryptophan 2,3-dioxygenase and a combined inhibitor of tryptophan 2,3-dioxygenase and 5-HT reuptake in the rat. Neuropharmacology 34:217-27 (1995). Read more (PubMed: 7617147) »

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