7-Cl-O-Nec1, metabolically stable RIP1 inhibitor (ab221984)

Overview

  • Product name

    7-Cl-O-Nec1, metabolically stable RIP1 inhibitor
  • Description

    Potent, selective, metabolically stable RIP1 inhibitor 
  • Alternative names

    • Nec-1s
    • Necrostatin-2 racemate
    • RIP1 Inhibitor II
  • Biological description

    Necrostatin-1 (ab141053) analog with superior selectivity and metabolic stability in blocking RIP1. No off-target inhibition of indolamine-2,3-deoxygenase (IDO) in contrast to Necrostatin-1. Higher activity in inhibiting necroptosis in Jurkat cells than Necrostatin-1 (EC50 = 210 nM vs. EC50 = 490 nM).

  • Purity

    > 98%
  • CAS Number

    852391-15-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5-((7-Chloro-1H-indol-3-yl)methyl)-3-methylimidazolidine-2,4-dione
  • Molecular weight

    277.71
  • Molecular formula

    C13H12ClN3O2
  • PubChem identifier

    643953
  • Storage instructions

    Shipped at room temperature. Store at -20°C.
  • Solubility overview

    Soluble in DMSO to 90 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CN1C(=O)C(NC1=O)CC2=CNC3=C2C=CC=C3Cl
  • Source

    Synthetic

References

This product has been referenced in:

  • Degterev A  et al. Activity and specificity of necrostatin-1, small-molecule inhibitor of RIP1 kinase. Cell Death Differ 20:366 (2013). Read more (PubMed: 23197295) »
  • Takahashi N  et al. Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models. Cell Death Dis 3:e437 (2012). Read more (PubMed: 23190609) »
  • Teng X  et al. Structure-activity relationship study of novel necroptosis inhibitors. Bioorg Med Chem Lett 15:5039-44 (2005). Read more (PubMed: 16153840) »

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