Overview

  • Product name

    7,3',4'-Trihydroxyisoflavone (7,3',4'-THIF), isoflavonoid
  • Description

    Isoflavone. Inhibits various kinase.
  • Alternative names

    • 7,3,4-THIF
  • Biological description

    Isoflavone. Inhibits PI3K, CDK, Cot and MKK4. Induces cell cycle arrest and suppresses proliferation.
  • Purity

    > 98%
  • CAS Number

    485-63-2
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Lo YL  et al. 7,3',4'-Trihydroxyisoflavone modulates multidrug resistance transporters and induces apoptosis via production of reactive oxygen species. Toxicology 302:221-32 (2012). Read more (PubMed: 22914566) »
  • Lee DE  et al. 7,3',4'-Trihydroxyisoflavone, a metabolite of the soy isoflavone daidzein, suppresses ultraviolet B-induced skin cancer by targeting Cot and MKK4. J Biol Chem 286:14246-56 (2011). Read more (PubMed: 21378167) »
  • Lee DE  et al. 7,3',4'-Trihydroxyisoflavone inhibits epidermal growth factor-induced proliferation and transformation of JB6 P+ mouse epidermal cells by suppressing cyclin-dependent kinases and phosphatidylinositol 3-kinase. J Biol Chem 285:21458-66 (2010). Read more (PubMed: 20444693) »

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