7,8-Dihydroxyflavone (7,8-DHF), TrkB receptor agonist. Flavonoid. (ab120996)
Key features and details
- Selective TrkB receptor agonist. Flavonoid.
- CAS Number: 38183-03-8
- Purity: > 99%
- Soluble in ethanol to 25 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
-
Product name
7,8-Dihydroxyflavone (7,8-DHF), TrkB receptor agonist. Flavonoid. -
Description
Selective TrkB receptor agonist. Flavonoid. -
Biological description
Selective TrkB receptor agonist. Flavonoid. Enhances synaptic plasticity in vivo and in vitro. Blood-brain barrier permeable.
-
Purity
> 99% -
CAS Number
38183-03-8 -
Chemical structure
Properties
-
Chemical name
7,8-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one -
Molecular weight
254.24 -
Molecular formula
C15H10O4 -
PubChem identifier
1880 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 25 mM and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
Oc3ccc1c(OC(=CC1=O)c2ccccc2)c3O -
Source
Synthetic
-
Research areas
Images
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (3)
ab120996 has been referenced in 3 publications.
- Fang X et al. Brain-derived neurotrophic factor-TrkB signaling in the medial prefrontal cortex plays a role in the anhedonia-like phenotype after spared nerve injury. Eur Arch Psychiatry Clin Neurosci 270:195-205 (2020). PubMed: 29882089
- Li S et al. Ketamine Alleviates Postoperative Depression-Like Symptoms in Susceptible Mice: The Role of BDNF-TrkB Signaling. Front Pharmacol 10:1702 (2019). PubMed: 32116688
- Huang N et al. Alterations in the BDNF-mTOR Signaling Pathway in the Spinal Cord Contribute to Hyperalgesia in a Rodent Model of Chronic Restraint Stress. Neuroscience 409:142-151 (2019). PubMed: 30940563