8-(3-Chlorostyryl)caffeine, A2A receptor antagonist. MAO-B inhibitor. (ab120442)

Overview

  • Product name

    8-(3-Chlorostyryl)caffeine, A2A receptor antagonist. MAO-B inhibitor.
  • Description

    Selective A2A receptor antagonist. MAO-B inhibitor.
  • Biological description

    Selective A2A receptor antagonist and MAO-B (monoamine oxidase B) inhibitor (Ki values are 54 and 100 nM, respectively). Affords strong neuroprotection against 6-OHDA-induced neurotoxicity in vitro and is neuroprotective in Parkinson's disease models.
  • Purity

    > 98%
  • CAS Number

    147700-11-6
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Nobre HV  et al. Caffeine and CSC, adenosine A2A antagonists, offer neuroprotection against 6-OHDA-induced neurotoxicity in rat mesencephalic cells. Neurochem Int 56:51-8 (2010). Read more (PubMed: 19782116) »
  • Chen JF  et al. 8-(3-Chlorostyryl)caffeine may attenuate MPTP neurotoxicity through dual actions of monoamine oxidase inhibition and A2A receptor antagonism. J Biol Chem 277:36040-4 (2002). Read more (PubMed: 12130655) »
  • Jacobson KA  et al. 8-(3-Chlorostyryl)caffeine (CSC) is a selective A2-adenosine antagonist in vitro and in vivo. FEBS Lett 323:141-4 (1993). Read more (PubMed: 8495727) »

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