8-(4-Chlorophenylthio)adenosine 3',5'-cyclic monophosphate (8-CPT-cAMP), Cell permeable cAMP analog. (ab120424)

Overview

  • Product name

    8-(4-Chlorophenylthio)adenosine 3',5'-cyclic monophosphate (8-CPT-cAMP), Cell permeable cAMP analog.
  • Description

    Cell permeable cAMP analog, protein kinase modulator
  • Alternative names

    • 8-CPT-cAMP
  • Biological description

    Membrane permeable, lipophilic, cAMP analog. Activator of Epac, cAMP and cGMP-dependent protein kinases (PKA/PKG). Displays site selectivity for Site B of cAMP-dependent PKA type II. Potently inhibits cyclic GMP-specific phosphodiesterase (PDE Va), PDE III and PDE IV (IC50 values are 0.9, 24 and 25 μM, respectively). Increases heart rate, causes fall in arterial blood pressure and vascular resistance in vivo.
  • Purity

    > 99%
  • CAS Number

    93882-12-3
  • Chemical structure

    Chemical Structure

Properties

Images

  • 1e7 3T3-L1 cells were treated for 15 minutes with 1 µM dexamethasone (ab120743) and 1 µg x mL-1 insulin (ab123768) with the addition of 50 µM forskolin (ab120058), 0.5 mM IBMX (ab120840) or 0.1 mM 8-CPT-cAMP (ab120424), extracted according to the protocol. Lysates were diluted 50-fold, and tested in duplicates (+/-SD).

References

This product has been referenced in:

  • Bartsch M  et al. Bioactivatable, membrane-permeant analogs of cyclic nucleotides as biological tools for growth control of C6 glioma cells. Biol Chem 384:1321-6 (2003). Read more (PubMed: 14515995) »
  • Whalen EJ  et al. Blockade of beta-adrenoceptors enhances cAMP signal transduction in vivo. Eur J Pharmacol 355:189-93 (1998). Read more (PubMed: 9760033) »
  • Connolly BJ  et al. 8-(4-Chlorophenyl)thio-cyclic AMP is a potent inhibitor of the cyclic GMP-specific phosphodiesterase (PDE VA). Biochem Pharmacol 44:2303-6 (1992). Read more (PubMed: 1335252) »

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