GTP analog. RNA triphosphatase and GTP-hydrolase inhibitor.
GTP analog. RNA triphosphatase and GTP-hydrolase inhibitor. Competitive FtsZ polymerization and GTPase inhibitor (IC50 = 32 μM). Competes with ATP but not UTP for the binding center of RNA-polymerase.
Store at -20°C (desiccating conditions).
Supplied in water (10 mM)
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Collier A & Wagner G A facile two-step synthesis of 8-arylated guanosine mono- and triphosphates (8-aryl GXPs). Org Biomol Chem4:4526-32 (2006).
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Läppchen T et al. GTP analogue inhibits polymerization and GTPase activity of the bacterial protein FtsZ without affecting its eukaryotic homologue tubulin. Biochemistry44:7879-84 (2005).
Read more (PubMed: 15910002) »
Kuriavyi VV et al. [Kinetics of inhibition by 8-oxy-GTP and 8-bromo-GTP of Escherichia coli RNA-polymerase synthesis of pppApU dinucleotide on the promotor a1 of phage T7deltaD111 DNA in a limited set of substrates]. Mol Biol (Mosk)23:822-9 (0).
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