8-Bromo-GTP (aqueous solution), GTP analog (ab146753)

Overview

  • Product name

    8-Bromo-GTP (aqueous solution), GTP analog
  • Description

    GTP analog. RNA triphosphatase and GTP-hydrolase inhibitor.
  • Biological description

    GTP analog. RNA triphosphatase and GTP-hydrolase inhibitor. Competitive FtsZ polymerization and GTPase inhibitor (IC50 = 32 μM). Competes with ATP but not UTP for the binding center of RNA-polymerase.
  • Purity

    > 95%
  • CAS Number

    23197-98-0
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    602.07
  • Molecular formula

    C10H15N5O14P3Br
  • Storage instructions

    Store at -20°C (desiccating conditions).
  • Solubility overview

    Supplied in water (10 mM)
  • Handling

    Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Collier A & Wagner G A facile two-step synthesis of 8-arylated guanosine mono- and triphosphates (8-aryl GXPs). Org Biomol Chem 4:4526-32 (2006). Read more (PubMed: 17268649) »
  • Läppchen T  et al. GTP analogue inhibits polymerization and GTPase activity of the bacterial protein FtsZ without affecting its eukaryotic homologue tubulin. Biochemistry 44:7879-84 (2005). Read more (PubMed: 15910002) »
  • Kuriavyi VV  et al. [Kinetics of inhibition by 8-oxy-GTP and 8-bromo-GTP of Escherichia coli RNA-polymerase synthesis of pppApU dinucleotide on the promotor a1 of phage T7deltaD111 DNA in a limited set of substrates]. Mol Biol (Mosk) 23:822-9 (0). Read more (PubMed: 2671676) »

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