8-Hydroxy-2'-deoxyguanosine, Oxidative stress biomarker (ab145595)

Overview

  • Product name

    8-Hydroxy-2'-deoxyguanosine, Oxidative stress biomarker
  • Description

    Oxidative stress biomarker
  • Biological description

    Oxidative stress biomarker. A predominant form of free radical-induced oxidative lesions in nuclear and mitochondrial DNA. Oxidized deoxyguanosine derivative. Biomarker for oxidative stress and carcinogenesis.
  • Purity

    > 98%
  • CAS Number

    88847-89-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-Amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3,7-dihydropurine-6,8-dione
  • Molecular weight

    283.24
  • Molecular formula

    C10H13N5O5
  • PubChem identifier

    73318
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1[C@@H]([C@H](O[C@H]1N2C3=C(C(=O)N=C(N3)N)NC2=O)CO)O
  • Source

    Synthetic

  • Research areas

Images

  • Pimonidazole staining and 8-Hydroxy-2'-deoxyguanosine expression in xenograft tumors.

    A, Hypoxia was detected in 2 mm (a), 5 mm (b), 10 mm (c) and 15 mm (d) tumors by pimonidazole staining.

References

This product has been referenced in:

  • Tuzcu M  et al. The effects of selenium supplementation on the spontaneously occurring fibroid tumors of oviduct, 8-hydroxy-2'-deoxyguanosine levels, and heat shock protein 70 response in Japanese quail. Nutr Cancer 62:495-500 (2010). Read more (PubMed: 20432170) »
  • Valavanidis A  et al. 8-hydroxy-2' -deoxyguanosine (8-OHdG): A critical biomarker of oxidative stress and carcinogenesis. J Environ Sci Health C Environ Carcinog Ecotoxicol 27:120-39 (2009). Read more (PubMed: 19412858) »
  • Kasai H Analysis of a form of oxidative DNA damage, 8-hydroxy-2'-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis. Mutat Res 387:147-63 (1997). Read more (PubMed: 9439711) »
See 1 Publication for this product

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