Overview

  • Product name
    9-cis-Retinoic acid
  • Description
    High affinity, endogenous retinoic acid receptor agonist
  • Biological description
    High affinity, endogenous retinoic acid receptor (RAR) agonist (IC50= 14 nM for RARα, RARβ and RARγ). Active metabolite of vitamin A. Acts as a transcription factor to regulate the growth and differentiation of normal and malignant cells and capable of inhibiting prostaglandin-endoperoxide synthase 2 expression.
  • Purity
    > 98%

Properties

References

This product has been referenced in:
  • Kane MA Analysis, occurrence, and function of 9-cis-retinoic acid. Biochim Biophys Acta 1821:10-20 (2012). Read more (PubMed: 21983272) »
  • Atikuzzaman M  et al. The 9-cis retinoic acid signaling pathway and its regulation of prostaglandin-endoperoxide synthase 2 during in vitro maturation of pig cumulus cell-oocyte complexes and effects on parthenogenetic embryo production. Biol Reprod 84:1272-81 (2011). Read more (PubMed: 21368300) »
  • Dmetrichuk JM  et al. Detection of endogenous retinoids in the molluscan CNS and characterization of the trophic and tropic actions of 9-cis retinoic acid on isolated neurons. J Neurosci 28:13014-24 (2008). Read more (PubMed: 19036995) »
  • Apfel C  et al. A retinoic acid receptor alpha antagonist selectively counteracts retinoic acid effects. Proc Natl Acad Sci U S A 89:7129-33 (1992). Read more (PubMed: 1323127) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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