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Rabbit polyclonal to ADAM20
Fusion protein corresponding to Human ADAM20 (internal sequence). Gene Accssion: BC025378.
Database link: O43506
PC3 and HeLa cell lysates; Human brain tissue.
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Preservative: 0.05% Sodium azide Constituents: 49% PBS, 50% Glycerol
Concentration information loading...
Immunogen affinity purified
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in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/25 - 1/100.
1/100 - 1/500. Predicted molecular weight: 82 kDa.
May be involved in sperm maturation and/or fertilization.
Contains 1 disintegrin domain.
Contains 1 EGF-like domain. Contains 1 peptidase M12B domain.
A tripeptide motif (VGE) within disintegrin-like domain could be involved in the binding to egg integrin receptor and thus could mediate sperm/egg binding.
The cysteine-rich domain encodes putative cell-fusion peptides, which could be involved in sperm-egg fusion. The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Has no obvious cleavage site for furin endopeptidase, suggesting that the proteolytic processing is regulated.
Information by UniProt
A disintegrin and metalloproteinase domain 20 antibody
A disintegrin and metalloproteinase domain 20 preproprotein antibody
Western blot - Anti-ADAM20 antibody (ab197829)
All lanes :
Anti-ADAM20 antibody (ab197829) at 1/100 dilution
Lane 1 :
PC3 cell lysate
Lane 2 :
HeLa cell lysate
Lysates/proteins at 40 µg per lane.
Predicted band size:
Gel: 8% SDS-PAGE
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ADAM20 antibody (ab197829)
Immunohistochemical analysis of paraffin-embedded Human brain tissue labeling ADAM20 with ab197829 at 1/30.
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"