Anti-AIMP2/p38 antibody (ab101840)
Key features and details
- Rabbit polyclonal to AIMP2/p38
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-AIMP2/p38 antibody
See all AIMP2/p38 primary antibodies -
Description
Rabbit polyclonal to AIMP2/p38 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat -
Immunogen
Recombinant fragment, corresponding to a region within amino acids 2-172 of Human AIMP2/p38 (AAH02853).
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 78.99% PBS, 1% BSA, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab101840 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/3000. Predicted molecular weight: 35 kDa.
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Notes |
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WB
1/500 - 1/3000. Predicted molecular weight: 35 kDa. |
Target
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Function
Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor. -
Sequence similarities
Contains 1 GST C-terminal domain. -
Post-translational
modificationsPhosphorylated on serine residues in response to UV irradiation.
Ubiquitinated by PARK2, leading to its degradation by the proteasome. Mutant PARK2 fails to ubiquitinate AIMP2 efficiently, allowing its accumulation which may contribute to neurodegeneration associated with Parkinson disease. -
Cellular localization
Cytoplasm > cytosol. Nucleus. Following DNA damage, dissociates from the aminoacyl-tRNA synthase complex and translocates from the cytoplasm to the nucleus. - Information by UniProt
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Database links
- Entrez Gene: 7965 Human
- Entrez Gene: 231872 Mouse
- Entrez Gene: 288480 Rat
- Omim: 600859 Human
- SwissProt: Q13155 Human
- SwissProt: Q8R010 Mouse
- SwissProt: Q32PX2 Rat
- Unigene: 301613 Human
see all -
Alternative names
- Aimp2 antibody
- AIMP2_HUMAN antibody
- Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (3)
ab101840 has been referenced in 3 publications.
- Wang YT et al. Fission Yeast Asc1 Stabilizes the Interaction between Eukaryotic Initiation Factor 3a and Rps0A/uS2 for Protein Synthesis. Mol Cell Biol 39:N/A (2019). PubMed: 31285271
- Park SJ et al. Evaluation of Multi-tRNA Synthetase Complex by Multiple Reaction Monitoring Mass Spectrometry Coupled with Size Exclusion Chromatography. PLoS One 10:e0142253 (2015). WB ; Human . PubMed: 26544075
- Kim K et al. Reinvestigation of aminoacyl-TRNA synthetase core complex by affinity purification-mass spectrometry reveals TARSL2 as a potential member of the complex. PLoS One 8:e81734 (2013). WB, IP ; Human . PubMed: 24312579