ALLM, calpain inhibitor (ab141446)
Key features and details
- Potent, cell-permeable calpain inhibitor. Highly potent cathepsin inhibitor.
- CAS Number: 136632-32-1
- Purity: > 95%
- Soluble in DMSO to 50 mM and in ethanol to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
ALLM, calpain inhibitor -
Description
Potent, cell-permeable calpain inhibitor. Highly potent cathepsin inhibitor. -
Purity
> 95% -
General notes
This product is manufactured by BioVision, an Abcam company and was previously called 1835 Calpain Inhibitor II, ALLM. 1835-25 is the same size as the 25 mg size of ab141446.
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CAS Number
136632-32-1 -
Chemical structure
Properties
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Molecular weight
401.57 -
Molecular formula
C19H35N3O4S -
Sequence
LLM (Modifications: N-terminal acetyl; C-terminal aldehyde) -
PubChem identifier
4331 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 50 mM and in ethanol to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CCSC)C=O)NC(=O)C -
Source
Synthetic
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Research areas
Associated products
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Related Products
- Cathepsin B Activity Assay Kit (Fluorometric) (ab65300)
- Cathepsin D Activity Assay Kit (Fluorometric) (ab65302)
- Cathepsin K Activity Assay Kit (Fluorometric) (ab65303)
- Cathepsin H Activity Assay Kit (Fluorometric) (ab65305)
- Cathepsin L Activity Assay Kit (Fluorometric) (ab65306)
- Calpain Activity Assay Kit (ab65308)
- Cathepsin D Inhibitor Assay Kit (ab126779)
- Cathepsin G Activity Assay Kit (Colorimetric) (ab126780)
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (3)
ab141446 has been referenced in 3 publications.
- Wu Y et al. Cathepsin B abundance, activity and microglial localisation in Alzheimer's disease-Down syndrome and early onset Alzheimer's disease; the role of elevated cystatin B. Acta Neuropathol Commun 11:132 (2023). PubMed: 37580797
- Wu Y et al. The effects of Cstb duplication on APP/amyloid-ß pathology and cathepsin B activity in a mouse model. PLoS One 16:e0242236 (2021). PubMed: 34292972
- Joy-Immediato M et al. Junctional ER Organization Affects Mechanotransduction at Cadherin-Mediated Adhesions. Front Cell Dev Biol 9:669086 (2021). PubMed: 34222239