Active human Cathepsin L full length protein (ab198444)

Overview

Description

  • Nature
    Recombinant
  • Source
    Mammalian
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      TLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYR EGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRS VDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLV DCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKY SVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEP DCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKD RRNHCGIASAASYPTV
    • Molecular weight
      36 kDa including tags
    • Amino acids
      18 to 333
    • Tags
      His tag C-Terminus
    • Additional sequence information
      This product is for the mature full length protein from aa 18 to 333. The signal peptide is not included.

Specifications

Our Abpromise guarantee covers the use of ab198444 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity

    Specific Activity: ≥ 990 pmol/min/µg

  • Applications

    SDS-PAGE

    Functional Studies

  • Purity
    > 80 % SDS-PAGE.

  • Form
    Liquid
  • Additional notes

    Expressed in FreeStyle 293-F cells.

    Useful for activation of DPP1 (Cathepsin C). Suitable for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on Dry Ice. Store at -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Preservative: 1.36% Imidazole
    Constituents: 20% Glycerol, 0.63% Tris HCl, 0.02% Potassium chloride, 0.64% Sodium chloride, 0.05% DTT

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • cathepsin L, 1 b
    • Cathepsin L1
    • Cathepsin L1 light chain
    • CathepsinL
    • CATL
    • CATL1_HUMAN
    • cb15
    • CTSL
    • CTSL1
    • ctsl1b
    • FLJ31037
    • hgg1
    • Major excreted protein
    • MEP
    • MGC123162
    • wu:fb30g09
    see all
  • Function
    Important for the overall degradation of proteins in lysosomes.
  • Sequence similarities
    Belongs to the peptidase C1 family.
  • Cellular localization
    Lysosome.
  • Information by UniProt

Images

  • 10% SDS-PAGE of  2.5μg ab198444.

  • Functional studies of ab198444. Specific Activity: 990 pmol/min/μg. Assay condition: Z-Leu-Arg-AMC (20 μM) was used as a substrate.

References

ab198444 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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