Anti-Alpha-synuclein (phospho S129) antibody [EP1536Y] (ab51253)

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ab51253 has been referenced in 58 publications.

  • Refolo V  et al. Progressive striatonigral degeneration in a transgenic mouse model of multiple system atrophy: translational implications for interventional therapies. Acta Neuropathol Commun 6:2 (2018). PubMed: 29298733
  • Rusconi R  et al. Long-lasting pathological consequences of overexpression-induced a-synuclein spreading in the rat brain. Aging Cell 17:N/A (2018). IHC-FrFl ; Rat . PubMed: 29383832
  • Magalhaes J  et al. Effects of ambroxol on the autophagy-lysosome pathway and mitochondria in primary cortical neurons. Sci Rep 8:1385 (2018). WB ; Mouse . PubMed: 29362387
  • Recasens A  et al. Lack of pathogenic potential of peripheral a-synuclein aggregates from Parkinson's disease patients. Acta Neuropathol Commun 6:8 (2018). IHC-FrFl ; Mouse . PubMed: 29422109
  • Svarcbahs R  et al. Removal of prolyl oligopeptidase reduces alpha-synuclein toxicity in cells and in vivo. Sci Rep 8:1552 (2018). PubMed: 29367610
  • Sano K  et al. Prion-Like Seeding of Misfolded a-Synuclein in the Brains of Dementia with Lewy Body Patients in RT-QUIC. Mol Neurobiol 55:3916-3930 (2018). WB ; Human . PubMed: 28550528
  • Wang L  et al. Seipin deficiency in mice causes loss of dopaminergic neurons via aggregation and phosphorylation of a-synuclein and neuroinflammation. Cell Death Dis 9:440 (2018). PubMed: 29670081
  • Tarutani A  et al. Potent prion-like behaviors of pathogenic a-synuclein and evaluation of inactivation methods. Acta Neuropathol Commun 6:29 (2018). IF, IHC, Electron Microscopy . PubMed: 29669601
  • Andersen MA  et al. Parkinson's disease-like burst firing activity in subthalamic nucleus induced by AAV-a-synuclein is normalized by LRRK2 modulation. Neurobiol Dis 116:13-27 (2018). WB ; Rat . PubMed: 29680709
  • Henrich MT  et al. A53T-a-synuclein overexpression in murine locus coeruleus induces Parkinson's disease-like pathology in neurons and glia. Acta Neuropathol Commun 6:39 (2018). PubMed: 29747690
  • De Miranda BR  et al. Astrocyte-specific DJ-1 overexpression protects against rotenone-induced neurotoxicity in a rat model of Parkinson's disease. Neurobiol Dis 115:101-114 (2018). IHC-P . PubMed: 29649621
  • Uemura N  et al. Inoculation of a-synuclein preformed fibrils into the mouse gastrointestinal tract induces Lewy body-like aggregates in the brainstem via the vagus nerve. Mol Neurodegener 13:21 (2018). IHC-FoFr ; Mouse . PubMed: 29751824
  • Colla E  et al. Toxic properties of microsome-associated alpha-synuclein species in mouse primary neurons. Neurobiol Dis 111:36-47 (2018). IF ; Human . PubMed: 29246724
  • Rey NL  et al. Spread of aggregates after olfactory bulb injection of a-synuclein fibrils is associated with early neuronal loss and is reduced long term. Acta Neuropathol 135:65-83 (2018). IF, IHC . PubMed: 29209768
  • Ngolab J  et al. Brain-derived exosomes from dementia with Lewy bodies propagate a-synuclein pathology. Acta Neuropathol Commun 5:46 (2017). IHC-P ; Human . PubMed: 28599681
  • Arawaka S  et al. Mechanisms underlying extensive Ser129-phosphorylation in a-synuclein aggregates. Acta Neuropathol Commun 5:48 (2017). WB . PubMed: 28619113
  • Ayers JI  et al. Robust Central Nervous System Pathology in Transgenic Mice following Peripheral Injection of a-Synuclein Fibrils. J Virol 91:N/A (2017). PubMed: 27852849
  • Karampetsou M  et al. Phosphorylated exogenous alpha-synuclein fibrils exacerbate pathology and induce neuronal dysfunction in mice. Sci Rep 7:16533 (2017). PubMed: 29184069
  • Gardner B  et al. Metal concentrations and distributions in the human olfactory bulb in Parkinson's disease. Sci Rep 7:10454 (2017). PubMed: 28874699
  • Zhao HT  et al. LRRK2 Antisense Oligonucleotides Ameliorate a-Synuclein Inclusion Formation in a Parkinson's Disease Mouse Model. Mol Ther Nucleic Acids 8:508-519 (2017). PubMed: 28918051
  • Wang J  et al. Protein arginylation targets alpha synuclein, facilitates normal brain health, and prevents neurodegeneration. Sci Rep 7:11323 (2017). IF . PubMed: 28900170
  • Longo F  et al. Age-dependent dopamine transporter dysfunction and Serine129 phospho-a-synuclein overload in G2019S LRRK2 mice. Acta Neuropathol Commun 5:22 (2017). IHC-FrFl, WB ; Mouse . PubMed: 28292328
  • de Oliveira RM  et al. The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease. PLoS Biol 15:e2000374 (2017). IHC ; Rat . PubMed: 28257421
  • Huang J  et al. HMGB1 Mediates Autophagy Dysfunction via Perturbing Beclin1-Vps34 Complex in Dopaminergic Cell Model. Front Mol Neurosci 10:13 (2017). WB ; Human . PubMed: 28197072
  • Mandel RJ  et al. Novel oligodendroglial alpha synuclein viral vector models of multiple system atrophy: studies in rodents and nonhuman primates. Acta Neuropathol Commun 5:47 (2017). IHC-P ; Rhesus monkey . PubMed: 28619074
  • Venezia S  et al. Toll-like receptor 4 stimulation with monophosphoryl lipid A ameliorates motor deficits and nigral neurodegeneration triggered by extraneuronal a-synucleinopathy. Mol Neurodegener 12:52 (2017). WB, IHC-FrFl ; Mouse . PubMed: 28676095
  • Rabl R  et al. Early start of progressive motor deficits in Line 61 a-synuclein transgenic mice. BMC Neurosci 18:22 (2017). PubMed: 28143405
  • Doucet-Beaupré H  et al. Lmx1a and Lmx1b regulate mitochondrial functions and survival of adult midbrain dopaminergic neurons. Proc Natl Acad Sci U S A 113:E4387-96 (2016). WB ; Mouse . PubMed: 27407143
  • Scheffold A  et al. Telomere shortening leads to an acceleration of synucleinopathy and impaired microglia response in a genetic mouse model. Acta Neuropathol Commun 4:87 (2016). IHC-P ; Mouse . PubMed: 27550225
  • Rutherford NJ  et al. Novel antibodies to phosphorylated a-synuclein serine 129 and NFL serine 473 demonstrate the close molecular homology of these epitopes. Acta Neuropathol Commun 4:80 (2016). PubMed: 27503460
  • Migdalska-Richards A  et al. Ambroxol effects in glucocerebrosidase and a-synuclein transgenic mice. Ann Neurol 80:766-775 (2016). WB ; Mouse . PubMed: 27859541
  • Gispert S  et al. Potentiation of neurotoxicity in double-mutant mice with Pink1 ablation and A53T-SNCA overexpression. Hum Mol Genet 24:1061-76 (2015). WB, IHC-P, IHC-FrFl ; Mouse . PubMed: 25296918
  • Sasaki A  et al. Sensitive western blotting for detection of endogenous Ser129-phosphorylated a-synuclein in intracellular and extracellular spaces. Sci Rep 5:14211 (2015). WB ; Human . PubMed: 26381815
  • Song LK  et al. Targeted Overexpression of a-Synuclein by rAAV2/1 Vectors Induces Progressive Nigrostriatal Degeneration and Increases Vulnerability to MPTP in Mouse. PLoS One 10:e0131281 (2015). ICC/IF . PubMed: 26114655
  • Spinelli KJ  et al. Curcumin Treatment Improves Motor Behavior in a-Synuclein Transgenic Mice. PLoS One 10:e0128510 (2015). PubMed: 26035833
  • Prusiner SB  et al. Evidence for a-synuclein prions causing multiple system atrophy in humans with parkinsonism. Proc Natl Acad Sci U S A 112:E5308-17 (2015). IHC-P ; Mouse . PubMed: 26324905
  • Woerman AL  et al. Propagation of prions causing synucleinopathies in cultured cells. Proc Natl Acad Sci U S A 112:E4949-58 (2015). PubMed: 26286986
  • Van der Perren A  et al. Longitudinal follow-up and characterization of a robust rat model for Parkinson's disease based on overexpression of alpha-synuclein with adeno-associated viral vectors. Neurobiol Aging 36:1543-58 (2015). WB ; Rat . PubMed: 25599874
  • Bourdenx M  et al. Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by a-synuclein overexpression. Acta Neuropathol Commun 3:46 (2015). IHC-FrFl ; Human . PubMed: 26205255
  • Postupna NO  et al. Flow cytometry analysis of synaptosomes from post-mortem human brain reveals changes specific to Lewy body and Alzheimer's disease. Lab Invest 94:1161-72 (2014). Flow Cyt . PubMed: 25068655
  • Bétemps D  et al. Alpha-synuclein spreading in M83 mice brain revealed by detection of pathological a-synuclein by enhanced ELISA. Acta Neuropathol Commun 2:29 (2014). WB, IHC . PubMed: 24624994
  • Neuner J  et al. A30P a-Synuclein interferes with the stable integration of adult-born neurons into the olfactory network. Sci Rep 4:3931 (2014). IHC-FrFl ; Mouse . PubMed: 24488133
  • Arawaka S  et al. Zonisamide attenuates a-synuclein neurotoxicity by an aggregation-independent mechanism in a rat model of familial Parkinson's disease. PLoS One 9:e89076 (2014). WB ; Rat . PubMed: 24586512
  • Pérez-Revuelta BI  et al. Metformin lowers Ser-129 phosphorylated a-synuclein levels via mTOR-dependent protein phosphatase 2A activation. Cell Death Dis 5:e1209 (2014). ICC/IF ; Mouse . PubMed: 24810045
  • Spinelli KJ  et al. Presynaptic alpha-synuclein aggregation in a mouse model of Parkinson's disease. J Neurosci 34:2037-50 (2014). WB, ICC/IF . PubMed: 24501346
  • Kellie JF  et al. Quantitative measurement of intact alpha-synuclein proteoforms from post-mortem control and Parkinson's disease brain tissue by intact protein mass spectrometry. Sci Rep 4:5797 (2014). WB ; Human . PubMed: 25052239
  • Beekes M  et al. Is there a risk of prion-like disease transmission by Alzheimer- or Parkinson-associated protein particles? Acta Neuropathol 128:463-76 (2014). IHC . PubMed: 25073522
  • Wang S  et al. Phosphatidylethanolamine deficiency disrupts a-synuclein homeostasis in yeast and worm models of Parkinson disease. Proc Natl Acad Sci U S A 111:E3976-85 (2014). PubMed: 25201965
  • Amschl D  et al. Time course and progression of wild type a-synuclein accumulation in a transgenic mouse model. BMC Neurosci 14:6 (2013). ICC/IF ; Human . PubMed: 23302418
  • Oliveras-Salvá M  et al. rAAV2/7 vector-mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration. Mol Neurodegener 8:44 (2013). WB . PubMed: 24267638
  • Janezic S  et al. Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model. Proc Natl Acad Sci U S A 110:E4016-25 (2013). WB ; Mouse . PubMed: 24082145
  • Chu Y  et al. Alterations in axonal transport motor proteins in sporadic and experimental Parkinson's disease. Brain 135:2058-73 (2012). ICC/IF ; Human . PubMed: 22719003
  • Wang S  et al. a-Synuclein disrupts stress signaling by inhibiting polo-like kinase Cdc5/Plk2. Proc Natl Acad Sci U S A 109:16119-24 (2012). WB . PubMed: 22988096
  • Foulds PG  et al. Phosphorylated a-synuclein can be detected in blood plasma and is potentially a useful biomarker for Parkinson's disease. FASEB J 25:4127-37 (2011). PubMed: 21865317
  • Mougenot AL  et al. Transmission of prion strains in a transgenic mouse model overexpressing human A53T mutated a-synuclein. J Neuropathol Exp Neurol 70:377-85 (2011). PubMed: 21487306
  • Mbefo MK  et al. Phosphorylation of synucleins by members of the Polo-like kinase family. J Biol Chem 285:2807-22 (2010). IHC-P ; Mouse . PubMed: 19889641
  • Liu P  et al. G protein-coupled receptor kinase 5, overexpressed in the alpha-synuclein up-regulation model of Parkinson's disease, regulates bcl-2 expression. Brain Res 1307:134-41 (2010). WB ; Human . PubMed: 19852948
  • Schell H  et al. Nuclear and neuritic distribution of serine-129 phosphorylated alpha-synuclein in transgenic mice. Neuroscience 160:796-804 (2009). ICC/IF, IHC-P ; Mouse . PubMed: 19272424


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