Bromocriptine mesylate, D2-like dopamine receptor agonist (ab120574)
Key features and details
- Potent, selective D2-like dopamine receptor agonist
- CAS Number: 22260-51-1
- Purity: > 99%
- Soluble in DMSO to 100 mM and in ethanol to 25 mM (with heating)
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Bromocriptine mesylate, D2-like dopamine receptor agonist -
Description
Potent, selective D2-like dopamine receptor agonist -
Biological description
Potent, selective D2-like dopamine receptor agonist (Ki values are ~8 (D2), ~5 (D3), ~290 (D4), ~440 (D1) and ~450 nM (D5)). Inhibits the release of pituitary prolactin and stimulates motor activity in Parkinson's disease. Also reverses glutamate transporter 1 (GLT-1) activity, increasing glutamate levels.
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Purity
> 99% -
CAS Number
22260-51-1 -
Chemical structure
Properties
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Chemical name
(5a)-2-Bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)ergotaman-3',6',18-trione methanesulfonate -
Molecular weight
750.70 -
Molecular formula
C32H40BrN5O5.CH3SO3H -
PubChem identifier
31100 -
Storage instructions
Store at +4°C. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 25 mM (with heating) -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CS(=O)(=O)O.Brc3nc2cccc1C4=C[C@H](CN(C)[C@@H]4Cc3c12)C(=O)N[C@@]7(O[C@]6(O)N([C@@H](CC(C)C)C(=O)N5CCC[C@H]56)C7=O)C(C)C -
Source
Synthetic
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Research areas
Images
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (1)
ab120574 has been referenced in 1 publication.
- Ji M et al. An Antiviral Peptide from Alopecosa nagpag Spider Targets NS2B-NS3 Protease of Flaviviruses. Toxins (Basel) 11:N/A (2019). PubMed: 31658707