Mouse, Rat, Human Predicted to work with:
Cow, Pig, Cynomolgus monkey, Orangutan
Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human CBR1 aa 200 to the C-terminus (Cysteine residue). The exact sequence is proprietary. Database link: P16152
293T, HeLa, MCF-7 and HepG2 cell lysates.
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents
This product is a recombinant rabbit monoclonal antibody.
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Western blot analysis on immunoprecipitation pellet from (1) HeLa cells lysate or (2) 1XPBS (negative control) using ab174852, and HRPconjugated anti-rabbit IgG preferentially detecting the non-reduced form of rabbit IgG.
Western blot - Anti-CBR1 [EPR9661(B)] antibody (ab174852)
All lanes : Anti-CBR1 antibody [EPR9661(B)] (ab174852) at 1/1000 dilution
Lane 1 : 293T cell lysate Lane 2 : HeLa cell lysate Lane 3 : MCF-7 cell lysate Lane 4 : HepG2 cell lysate
Tak E et al. Epigallocatechin-3-gallate protects against hepatic ischaemia-reperfusion injury by reducing oxidative stress and apoptotic cell death. J Int Med Res44:1248-1262 (2016).
Read more (PubMed: 27807255) »