Anti-CCR6 antibody (ab78429)
Key features and details
- Rabbit polyclonal to CCR6
- Suitable for: WB
- Reacts with: Rat, Human
- Isotype: IgG
Get better batch-to-batch reproducibility with a recombinant antibody
- Research with confidence – consistent and reproducible results with every batch
- Long-term and scalable supply – powered by recombinant technology for fast production
- Success from the first experiment – confirmed specificity through extensive validation
- Ethical standards compliant – production is animal-free
Overview
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Product name
Anti-CCR6 antibody
See all CCR6 primary antibodies -
Description
Rabbit polyclonal to CCR6 -
Host species
Rabbit -
Specificity
No cross reactivity with other proteins.
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Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Rat, Human
Predicted to work with: Mouse, Dog -
Immunogen
Synthetic peptide corresponding to Human CCR6 aa 358-374 (C terminal). Different from the related rat and mouse sequences by two amino acids.
Sequence:RQTSETADNDNASSFTM
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Positive control
- WB: Rat liver tissue lysate and SW620 and CEM cell lysates.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
Preservative: 0.025% Sodium azide
Constituents: 0.45% Sodium chloride, 0.1% Dibasic monohydrogen sodium phosphate, 2% Trehalose -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab78429 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
Use a concentration of 0.1 - 0.5 µg/ml. Predicted molecular weight: 42 kDa.
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Notes |
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WB
Use a concentration of 0.1 - 0.5 µg/ml. Predicted molecular weight: 42 kDa. |
Target
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Function
Receptor for a C-C type chemokine. Binds to MIP-3-alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level. -
Tissue specificity
Spleen, lymph nodes, appendix, and fetal liver. Expressed in lymphocytes, T-cells and B-cells but not in natural killer cells, monocytes or granulocytes. -
Sequence similarities
Belongs to the G-protein coupled receptor 1 family. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 1235 Human
- Entrez Gene: 12458 Mouse
- Entrez Gene: 308163 Rat
- Omim: 601835 Human
- SwissProt: P51684 Human
- SwissProt: O54689 Mouse
- Unigene: 46468 Human
- Unigene: 8007 Mouse
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Alternative names
- BN 1 antibody
- BN1 antibody
- C C chemokine receptor type 6 antibody
see all
Images
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (15)
ab78429 has been referenced in 15 publications.
- Shigeoka M et al. Tongue Cancer Cell-Derived CCL20 Induced by Interaction With Macrophages Promotes CD163 Expression on Macrophages. Front Oncol 11:667174 (2021). PubMed: 34178651
- Bharucha JP et al. Human Beta-Defensin 2 and 3 Inhibit HIV-1 Replication in Macrophages. Front Cell Infect Microbiol 11:535352 (2021). PubMed: 34277460
- Ahn JH et al. Age-dependent alterations in the immunoreactivity of macrophage inflammatory protein-3a and its receptor CCR6 in the gerbil hippocampus. Mol Med Rep 22:1317-1324 (2020). PubMed: 32627009
- Wang T et al. Alleviation of Synovial Inflammation of Juanbi-Tang on Collagen-Induced Arthritis and TNF-Tg Mice Model. Front Pharmacol 11:45 (2020). PubMed: 32116720
- Chang KC et al. Stem cell characteristics promote aggressiveness of diffuse large B-cell lymphoma. Sci Rep 10:21342 (2020). PubMed: 33288848