Anti-CHRDL1 antibody (ab103369)
Key features and details
- Rabbit polyclonal to CHRDL1
- Suitable for: WB
- Reacts with: Mouse, Human
- Isotype: IgG
Overview
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Product name
Anti-CHRDL1 antibody
See all CHRDL1 primary antibodies -
Description
Rabbit polyclonal to CHRDL1 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Mouse, Human -
Immunogen
Recombinant full length protein, corresponding to amino acids 1-450 of Human CHRDL1 (ENSP00000361115)
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.4
Constituent: PBS -
Concentration information loading...
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Purity
Protein A purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab103369 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/1000. Predicted molecular weight: 51 kDa.
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Notes |
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WB
1/500 - 1/1000. Predicted molecular weight: 51 kDa. |
Target
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Function
Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embyonic bone formation (By similarity). May also play an important role in regulating retinal angiogenesis trough modulation of BMP4 actions in endothelial cells. -
Tissue specificity
Expressed in retinal pericytes. -
Sequence similarities
Contains 3 VWFC domains. -
Cellular localization
Secreted. - Information by UniProt
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Database links
- Entrez Gene: 91851 Human
- Entrez Gene: 83453 Mouse
- Omim: 300350 Human
- SwissProt: Q9BU40 Human
- SwissProt: Q920C1 Mouse
- Unigene: 496587 Human
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Alternative names
- CHL antibody
- chordin like 1 antibody
- Chordin-like protein 1 antibody
see all
Images
Datasheets and documents
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Datasheet download
References (2)
ab103369 has been referenced in 2 publications.
- Liu T et al. Chordin-Like 1 Improves Osteogenesis of Bone Marrow Mesenchymal Stem Cells Through Enhancing BMP4-SMAD Pathway. Front Endocrinol (Lausanne) 10:360 (2019). PubMed: 31249554
- Cyr-Depauw C et al. Chordin-Like 1 Suppresses Bone Morphogenetic Protein 4-Induced Breast Cancer Cell Migration and Invasion. Mol Cell Biol 36:1509-25 (2016). PubMed: 26976638