Anti-CXCR1 antibody (ab124344)
Key features and details
- Rabbit polyclonal to CXCR1
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
-
Product name
Anti-CXCR1 antibody
See all CXCR1 primary antibodies -
Description
Rabbit polyclonal to CXCR1 -
Host species
Rabbit -
Tested applications
Suitable for: WB, IHC-Pmore details -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide derived from the N terminus of Human CXCR1 (NP_000625).
-
Positive control
- Human fetal skin lysate; Human fetal tonsil tissue.
-
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
-
Form
Lyophilized:Reconstitute in 200ul of sterile H2O. The lyophilized antibody is stable for at least one year when stored at -20ºC after reconstitution. -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 98% PBS, 1% BSA -
Concentration information loading...
-
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
-
Compatible Secondaries
-
Isotype control
-
Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab124344 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
WB |
1/500 - 1/1000. Predicted molecular weight: 40 kDa.
|
|
IHC-P |
1/100 - 1/500.
|
Notes |
---|
WB
1/500 - 1/1000. Predicted molecular weight: 40 kDa. |
IHC-P
1/100 - 1/500. |
Target
-
Function
Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity. -
Sequence similarities
Belongs to the G-protein coupled receptor 1 family. -
Cellular localization
Cell membrane. - Information by UniProt
-
Database links
- Entrez Gene: 3577 Human
- Omim: 146929 Human
- SwissProt: P25024 Human
- Unigene: 194778 Human
-
Alternative names
- C C antibody
- C C CKR 1 antibody
- C-X-C chemokine receptor type 1 antibody
see all
Images
Protocols
Datasheets and documents
-
SDS download
-
Datasheet download
References (5)
ab124344 has been referenced in 5 publications.
- Le A et al. MiR-144-induced KLF2 inhibition and NF-kappaB/CXCR1 activation promote neutrophil extracellular trap-induced transfusion-related acute lung injury. J Cell Mol Med 25:6511-6523 (2021). PubMed: 34120407
- Ren J et al. Long non-coding RNA PCED1B antisense RNA 1 promotes gastric cancer progression via modulating microRNA-215-3p / C-X-C motif chemokine receptor 1 axis. Bioengineered 12:6083-6095 (2021). PubMed: 34516330
- Ilgin C et al. The evaluation of the distribution of CD133, CXCR1 and the tumor associated macrophages in different molecular subtypes of breast cancer. Histol Histopathol N/A:18139 (2019). PubMed: 31250425
- Wang S et al. miR-761 inhibits human osteosarcoma progression by targeting CXCR1. Int J Clin Exp Pathol 11:5327-5334 (2018). PubMed: 31949613
- Kokje VBC et al. CXCL8 hyper-signaling in the aortic abdominal aneurysm. Cytokine 108:96-104 (2018). IHC-P ; Human . PubMed: 29587155