Human Predicted to work with:
Recombinant fragment, corresponding to amino acids 48-281 of Human Centaurin alpha 2 (BC033758).
Human fetal spleen and Human fetal kidney lysates (WB)
Human fetal spleen tissue (IHC)
Lyophilised:Reconstitute with 200ul distilled sterile water. Please note that if you receive this product in liquid form it has already been reconstituted as described and no further reconstitution is necessary.
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity.
Highly expressed in placenta, spleen, kidney, skeletal muscle and adrenal gland. Weakly expressed in thyroid, liver, heart, lung, small intestine, peripheral blood leukocytes. Not detected in spinal cord, brain, stomach, trachea, colon, lymph node and bone marrow.
Contains 1 Arf-GAP domain. Contains 2 PH domains.
Cytoplasm. Cell membrane. Constitutively associated with the plasma membrane. Excluded from the nucleus.
Bist P et al. ArfGAP Domain-Containing Protein 2 (ADAP2) Integrates Upstream and Downstream Modules of RIG-I Signaling and Facilitates Type I Interferon Production. Mol Cell Biol37:N/A (2017).
Read more (PubMed: 27956705) »