Overview

  • Product name
    Anti-Creatine kinase MT antibody
    See all Creatine kinase MT primary antibodies
  • Description
    Rabbit polyclonal to Creatine kinase MT
  • Host species
    Rabbit
  • Specificity
    ab198257 detects endogenous levels of total Creatine kinase MT protein.
  • Tested applications
    Suitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rat
  • Immunogen

    Synthetic peptide within Human Creatine kinase MT (internal sequence). The exact sequence is proprietary.
    Database link: P12532

  • Positive control
    • Mouse crassum intestinum tissue lysate, paraffin-embedded Human tonsil tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab198257 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/200.
WB 1/1000 - 1/3000. Predicted molecular weight: 47 kDa.

Target

  • Relevance
    Creatine kinase MT is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Creatine kinase MT occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase, this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase.
  • Cellular localization
    Cell Membrane and Mitochondrial
  • Database links
  • Alternative names
    • Acidic type mitochondrial creatine kinase antibody
    • CKMT antibody
    • CKMT1 antibody
    • CKMT1A antibody
    • CKMT1B antibody
    • Creatine kinase mitochondrial 1 ubiquitous antibody
    • Creatine kinase U type, mitochondrial antibody
    • Creatine kinase ubiquitous mitochondrial antibody
    • Creatine kinase, mitochondrial 1 (ubiquitous) antibody
    • Creatine kinase, mitochondrial 1A antibody
    • Creatine kinase, mitochondrial 1B antibody
    • Mia CK antibody
    • U MtCK antibody
    • Ubiquitous mitochondrial creatine kinase antibody
    • UMTCK antibody
    see all

Images

  • Anti-Creatine kinase MT antibody (ab198257) at 1/1500 dilution + Mouse crassum intestinum tissue lysate at 30 µg

    Predicted band size: 47 kDa


    Exposure time: 1 minute
  • Immunohistochemical analysis of paraffin-embedded Human tonsil tissue labeling Creatine kinase MT using ab198257 at 1/80 dilution.

References

ab198257 has not yet been referenced specifically in any publications.

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