• Product name
    Anti-Cytochrome P450 2D1 antibody
    See all Cytochrome P450 2D1 primary antibodies
  • Description
    Rabbit polyclonal to Cytochrome P450 2D1
  • Host species
  • Specificity
    ab22590 recognises cytochrome P450 2D1 (CYP2D1).
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Rat
  • Immunogen

    Synthetic hexapeptide including the C terminal of rat liver CYP2D1 which was conjugated to keyhole limpet haemocyanin using a maleimido linkage.

  • Positive control
    • rat and human liver microsomal preparations.



Our Abpromise guarantee covers the use of ab22590 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notes
    WB: Use at an assay dependent dilution. Predicted molecular weight: 57 kDa.

    Note: to dilute ab22590, use the following solution: 50mM Tris HCl buffer (pH 7.6) containing 1.5% sodium chloride and 1% normal goat serum (if a goat anti rabbit IgG linker antibody is to be used).

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Relevance
      The cytochrome P450 superfamily of heme thiolate mono oxygenases play a key role in the oxidative metabolism of many endogenous and exogenous molecules, and are classified by their primary structure into four main groups. It is an ancient superfamily, which has been identified in prokaryotes and in many types of eukaryotic cells. The CYP2A sub family is found in the liver, and recently in the nasal mucosa where they are involved in the metabolism of inhaled xenobiotics and nicotine. CYP2B proteins are found in the liver, where they are involved in the metabolism of hepatic drugs, and in the lung and brain, whereas the CYP2C proteins are involved in the metabolism of anti depressants. CYP2E1 is alcohol inducible, and found principally in the liver. Rat CYP2D1, the homologue of human CYP2D6, has been shown to catalyse the conversion of hydrocodone to hydromorphone, and in rat liver microsomes it participates in the conversion of ethylmorphine to codeine and morphine. Its regional distribution in the rat brain has been described. Mutation in the cyp2D6 gene has been reported to be associated with PD10.
    • Cellular localization
      Membrane bound. Endoplasmic reticulum.
    • Database links
    • Alternative names
      • Cyp2d1 antibody
      • Cyp2d9 antibody
      • Cytochrome P450 2D1 antibody
      • Debrisoquine 4 hydroxylase antibody
      • P450 DB1 antibody
      see all


    This product has been referenced in:
    • Agus HH  et al. Drug interaction potential of the seed extract of Urtica urens L. (dwarf nettle). Phytother Res 23:1763-70 (2009). WB ; Rat . Read more (PubMed: 19441062) »
    See 1 Publication for this product

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