Anti-DR6 antibody (ab8417)
Key features and details
- Rabbit polyclonal to DR6
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-DR6 antibody
See all DR6 primary antibodies -
Description
Rabbit polyclonal to DR6 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide corresponding to Human DR6 aa 42-56.
Sequence:QPEQKASNLIGTYRHC
(Peptide available asab8450) -
Positive control
- WB: HeLa and K562 whole cell lysates.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C. -
Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading...
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Purity
DEAE-Chromatography -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab8417 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/2000. Detects a band of approximately 68 kDa.
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Notes |
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WB
1/500 - 1/2000. Detects a band of approximately 68 kDa. |
Target
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Function
May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). -
Tissue specificity
Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes. -
Sequence similarities
Contains 1 death domain.
Contains 4 TNFR-Cys repeats. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 27242 Human
- Omim: 605732 Human
- SwissProt: O75509 Human
- Unigene: 443577 Human
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Alternative names
- TNFRSF 21 antibody
- BM 018 antibody
- BM018 antibody
see all
Images
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All lanes : Anti-DR6 antibody (ab8417) at 1/500 dilution
Lane 1 : K562 whole cell lysate with absence of blocking peptide
Lane 2 : Raji whole cell lysate with absence of blocking peptide
Lane 3 : K562 whole cell lysate with Human DR6 peptide (ab8450)
Lane 4 : Raji whole cell lysate with Human DR6 peptide (ab8450)
Observed band size: 68 kDa why is the actual band size different from the predicted?
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab8417 has been referenced in 2 publications.
- Zhang T et al. Amyloid precursor protein binds with TNFRSF21 to induce neural inflammation in Alzheimer's Disease. Eur J Pharm Sci 157:105598 (2021). PubMed: 33075465
- Klíma M et al. Functional analysis of the posttranslational modifications of the death receptor 6. Biochim Biophys Acta 1793:1579-87 (2009). WB ; Human . PubMed: 19654028